Effects of dietary lipids on renal function of aged rats

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dc.contributor.author Valente Gamba, C. [UNIFESP]
dc.contributor.author Zeraib Caraviello, A. [UNIFESP]
dc.contributor.author Matsushita, A. [UNIFESP]
dc.contributor.author Alves, G.m. [UNIFESP]
dc.contributor.author Nunes da Silva, L. [UNIFESP]
dc.contributor.author Nascimento Gomes, G. [UNIFESP]
dc.contributor.author Gil, Frida Zaladek [UNIFESP]
dc.date.accessioned 2015-06-14T13:29:17Z
dc.date.available 2015-06-14T13:29:17Z
dc.date.issued 2001-02-01
dc.identifier http://dx.doi.org/10.1590/S0100-879X2001000200016
dc.identifier.citation Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 2, p. 265-269, 2001.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/1112
dc.description.abstract Normal aging is accompanied by renal functional and morphological deterioration and dietetic manipulation has been used to delay this age-related decline. We examined the effects of chronic administration of diets containing 5% lipid-enriched diet (LD, w/w) on renal function of rats at different ages. Three types of LD were tested: canola oil, fish oil and butter. Mean systemic tail-cuff blood pressure and glycemia remained within the normal range whatever the age and the diet of the animals. Proteinuria began to rise from the 8th month in the groups ingesting LD, while in the control group it increased significantly (above 10 mg/24 h) only after the 10th month. With age, a significant and progressive decline in glomerular filtration rate (GFR) and renal plasma flow was observed in the LD groups but after 6 months of lipid supplementation, the decline in these parameters was more marked in the butter and fish oil groups. By the 18th month, the lowest GFR level was observed in the group ingesting the butter diet (2.93 ± 0.22 vs 5.01 ± 0.21 ml min-1 kg-1 in control, P<0.05). Net acid excretion, evaluated in 9- and 18-month-old rats, was stimulated in the fish oil group when compared both to control and to the other two LD groups. These results suggest that even low levels of LD in a chronic nutritional regimen can modify the age-related changes in renal function and that the impact of different types of lipid-supplemented diets on renal function depends on the kind of lipid present in the diet. en
dc.format.extent 265-269
dc.language.iso eng
dc.publisher Associação Brasileira de Divulgação Científica
dc.relation.ispartof Brazilian Journal of Medical and Biological Research
dc.rights Acesso aberto
dc.subject aging en
dc.subject lipids en
dc.subject proteinuria en
dc.subject renal function en
dc.subject acid excretion en
dc.subject canola oil en
dc.subject fish oil en
dc.title Effects of dietary lipids on renal function of aged rats en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Disciplina de Fisiologia Renal e Termometabologia
dc.description.affiliationUnifesp UNIFESP, EPM, Disciplina de Fisiologia Renal e Termometabologia
dc.identifier.file S0100-879X2001000200016.pdf
dc.identifier.scielo S0100-879X2001000200016
dc.identifier.doi 10.1590/S0100-879X2001000200016
dc.description.source SciELO
dc.identifier.wos WOS:000167337600016



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