Navegando por Palavras-chave "young adult"

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    Osteosarcoma in patients younger than 12 years old without metastases have similar prognosis as adolescent and young adults
    (Wiley-Blackwell, 2015-07-01) Prates Eleuterio, Sabrina Jeane [UNIFESP]; Senerchia, Andreza Almeida [UNIFESP]; Almeida, Maria Teresa; Da Costa, Cecilia Maria; Lustosa, Daniel; Calheiros, Luiz Mario; Silva Barreto, Jose Henrique; Brunetto, Algemir Lunardi; Pacheco Donato Macedo, Carla Renata [UNIFESP]; Petrilli, Antonio Sergio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); Hosp Canc AC Camargo; Hosp Canc Ceara; Soc Pernambucana Combate Ao Canc; Soc Oncol Bahia; Hosp Clin Porto Alegre
    BackgroundChildhood cancer is relatively rare and tends to present specific age distribution, as a prognostic factor for some of these diseases. Information on how young age affects prognosis, response to chemotherapy, and local control options in children versus AYA with osteosarcoma (OST) is minimal.MethodsIn order to identify the main differences in clinicalpathologic features, surgical approaches and survival rates of primary high grade OST of the extremity between children (n=156; <12 years old) and AYA (n=397; 12-30 years old), the institutional database with 553 patients treated by BOTG studies over 15 years were reviewed.ResultsThere were no differences in metastasess at diagnosis, tumor size, and grade of necrosis between the two age groups. the rate of amputation was 30% higher in the children group (P=0.018). the rate of limb salvage surgery using reconstruction with allograft or autograft was 70% higher in the children group (P=0.018) while endoprosthesis rate was 40% higher in the AYA group (P=0.018). the log rank test revealed that survival is similar between the two age groups for non-metastatic patients (P=0.424 for OS and P=0.393 for EFS). Metastatic patients of both ages group had higher risk of dying compared to non-metastatic (HR 3.283 95% CI 2.581-4.177; P<0.001). Children with metastases at diagnosis had less OS time (P=0.049) and EFS time (P=0.032) than adolescents.ConclusionNon-metastatic OST in preadolescent patients does not appear to be significantly differentfrom those seen in AYA patients, but has local control challenges. Children presenting with metastases should be considered an ultra-high-risk group. Pediatr Blood Cancer 2015;62:1209-1213. (c) 2015 Wiley Periodicals, Inc.
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    Trends in Incidence of Primary Cutaneous Malignancies in Children, Adolescents, and Young Adults: A Population-Based Study
    (Wiley-Blackwell, 2014-02-01) Senerchia, Andreza A. [UNIFESP]; Ribeiro, Karina B.; Rodriguez-Galindo, Carlos; Universidade Federal de São Paulo (UNIFESP); Santa Casa São Paulo; Harvard Univ
    BackgroundSkin cancer incidence among young adults is rising; however, the epidemiological characteristics of primary cutaneous lymphomas and cutaneous soft tissue sarcomas (CSTS) in individuals <30 years old has not been investigated. We analyzed the incidence and time-trends of primary cutaneous malignancies in children and adolescents/young adults (AYA).ProcedureSEER-17 and -13 data were used to assess the descriptive epidemiology and time-trends in incidence of primary cutaneous malignancies in children and AYA. SEERStat and Joinpoint softwares were utilized to estimate annual percent changes (APC) in incidence.ResultsIn total, 7,814 cases (ASR=25.66/1,000,000 habitants) of primary skin cancers in <30 years old were diagnosed in 2000-2008. Females had a higher incidence of melanoma (risk ratio (RR)=1.95; P<0.001) and a lower risk of developing CSTS (RR=0.64, P<0.001). Compared to whites, blacks have a lower incidence of melanoma (RR=0.03, P<0.001), and higher risk of CSTS (RR=2.28, P<0.001). Melanoma increased in females over a 15-year period (1992-2006) (APC=2.5, 95%CI=1.8; 3.2), and the incidence of cutaneous T-cell lymphomas increased over the period 1992-2008 (APC=9.5, 95% CI=6.7; 12.4). CSTS incidence decreased among males over the period 1992-1999 (APC=-21.4, 95% CI -27.2; -15.1), particularly due to a decrease in Kaposi sarcoma incidence (AAPC 1992-2008=-13.6, 95% CI=-22.4;-3.8), although with a notable racial disparity (whites, AAPC=-15.2, 95% CI=-23.2;-6.4; blacks, AAPC=-10.6, 95% CI=-13.2;-7.9).ConclusionsNon-melanoma skin cancer is very rare in children and AYA. We have shown variation in time-trends in incidence as well as in incidence patterns by race, sex, age, and histologic type, highlighting the importance of descriptive epidemiology to better understand the characteristics of these malignancies. Pediatr Blood Cancer 2014;61:211-216. (c) 2013 Wiley Periodicals, Inc.
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    Vulnerabilidade ao papiloma vírus humano em universitários de Bogotá / Colômbia
    (Universidade Federal de São Paulo (UNIFESP), 2014-08-08) Sepúlveda-Carrillo, Gloria Judith [UNIFESP]; Goldenberg, Paulete [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Introduction: The Human Papilloma Virus (VPH), whether by the magnitude of its length, whether the implications in triggering of several forms of cancer, among them the cancer of the cervix, is a serious public health problem. Objective: To identify knowledge and preventive practices related to VPH infection, in view of vulnerability among the university students of Bogotá-Colombia. Method: The work consisted of three linked movements. In the first one, a systematic literature review regarding the subject of research was conducted, in order to subsidize the preparation of a questionnaire to be applied to a sample of university students. In the second movement proceeded to the construction and validation of the questionnaire. Finally, the third movement involved the application of the questionnaire among the university students of Bogota ? Colombia in 2012. Results: The literature review highlighted the limitations of knowledge by the young adult population and the urgency of conducting diagnostics able to subsidize the adoption of specific measures to deal with HPV. In the second stage, was performed content validity of questionnaire of vulnerability to HPV; showed that the questionnaire had adequate validity indicators content being approved to use. In the third step was realized a diagnosis with college students to determine knowledge and preventive practices about HPV. The study indicated that is limited, the level of student knowledge about the transmission, development and severity of HPV infection. Conclusion: In consonance with the concept of vulnerability ? the need to propose interventions in the context of public health is clearly notorious, directed towards improving knowledge about VPH, with the raising of awareness to the adoption of consistent behaviors.