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    Long-Term Effects of Anterior Thalamic Nucleus Deep Brain Stimulation on Spatial Learning in the Pilocarpine Model of Temporal Lobe Epilepsy
    (Wiley, 2018) Ferreira, Elenn Soares [UNIFESP]; Vieira, Lais Gabrielle [UNIFESP]; Moraes, Daniela Macedo [UNIFESP]; Amorim, Beatriz O. [UNIFESP]; Malheiros, Jackeline Moraes [UNIFESP]; Hamani, Clement; Covolan, Luciene [UNIFESP]
    Introduction and ObjectivesCognitive impairment is a significant comorbidity of temporal lobe epilepsy that is associated with extensive hippocampal cell loss. Deep brain stimulation (DBS) of the anterior thalamic nucleus (ANT) has been used for the treatment of refractory partial seizures. In the pilocarpine model of epilepsy, ANT DBS applied during status epilepticus (SE) reduces hippocampal inflammation and apoptosis. When given to chronic epileptic animals it reduces hippocampal excitability and seizure frequency. Here, we tested whether ANT DBS delivered during SE and the silent phase of the pilocarpine model would reduce cognitive impairment when animals became chronically epileptic. Materials and MethodsSE was induced by a systemic pilocarpine injection (320 mg/kg). Immediately after SE onset, rats were assigned to receive DBS during the first six hours of SE (n=8