Navegando por Palavras-chave "vocal fold"
Agora exibindo 1 - 6 de 6
Resultados por página
Opções de Ordenação
- ItemSomente MetadadadosConcentração do ácido hialurônico em pregas vocais com edema de reinke(Universidade Federal de São Paulo (UNIFESP), 2016-11-29) Melo, Cristiana Vanderlei de [UNIFESP]; Biase, Noemi Grigoletto de Biase [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objective: The authors investigated the concentration of hyaluronic acid in Reinke's edema in the vocal fold cover. Method: For this study a hyaluronic acid binding protein isolated from bovine nasal cartilage was used. Plates containing the binding protein were successively incubated with 32 samples Reinke?s edema and 11 female vocal folds; biotin-conjugated hyaluronic acid binding protein and europium-labeled. After release of europium from streptavidin with enhancement solution the final flourescence was measured in a fluorometer. Results: Were evaluated 19 patients with Reinke's edema, with a predominance of the female sex (94%) with mean age of 57.62 years. The concentration of hyaluronic acid in vocal folds with Reinke's edema was greater and statistically significant relative to the control. There was no statistical difference between the concentration of hyaluronic acid in the samples with Reinke's edema in relation to age, grade or smoking history.Conclusion: The study of hyaluronic acid concentration in vocal folds with Reinke's edema, we conclude that vocal folds affected by Reinke's edema have higher concentrations of hyaluronic acid in relation to normal; and the concentration of hyaluronic acid is independent of age, the degree of Reinke's edema or smoking history.
- ItemAcesso aberto (Open Access)Diferenciação histopatológica e imunoistoquímica das alterações epiteliais no nódulo vocal em relação aos pólipos e ao edema de laringe(ABORL-CCF Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial, 2004-08-01) Neves, Beatrice M. J. [UNIFESP]; G. Neto, João; Pontes, Paulo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)AIM: To evaluate by histological and immunohistochemical methods the epithelial lesions in vocal nodule and correlate with polyp, laryngeal edema and vocal folds without macroscopic lesions. STUDY DESIGN: Chart review. MATERIAL AND METHOD: In a retrospective analysis of medical records, twenty-six patients, who underwent microsurgical excision of laryngeal inflammatory lesions (nodules, polyps and laryngeal edema), were identified. Vocal folds without macroscopic lesions were obtained from autopsy. To evaluate epithelial lesions, specimens were stained with H&E, PAS, and with antibodies against laminin and collagen type IV. These specimens were analyzed by light microscopy. RESULTS: Lesions diagnosed as nodules showed more collagen type IV and laminin deposition when compared to polyps (p=0,034 and p=0,036, respectively) and to vocal folds without macroscopic lesions (p=0,019 and p=0,021, respectively). Nodules showed basement membranes thicker than polyps on PAS stain (p=0,102). Laryngeal edema could not be differentiated from nodules, polyps or vocal folds without macroscopic lesions by PAS, laminin or collagen type IV stain (p>0,10). CONCLUSION: By histological and immunohistochemical techniques to evaluate epithelium of laryngeal inflammatory lesions we conclude that vocal fold nodule differentiate from polyps on the three techniques used to stain basement membrane (PAS, laminin, collagen IV) and from vocal folds without macroscopic lesions on two techniques used (laminin, collagen IV). Laryngeal edema cannot be differentiated from the others laryngeal lesions, neither from vocal folds without macroscopic lesions, when the techniques before described are used.
- ItemAcesso aberto (Open Access)Distonia laríngea de adução: proposta e avaliação de protocolo de nasofibrolaringoscopia(ABORL-CCF Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial, 2006-08-01) De Biase, Noemi Grigoletto [UNIFESP]; Lorenzon, Paula [UNIFESP]; Lebl, Mariana Dantas Aumond [UNIFESP]; Padovani, Marina Martins Pereira [UNIFESP]; Gielow, Ingrid [UNIFESP]; Madazio, Glaucya [UNIFESP]; Moraes, Miriam; Pontifícia Universidade Católica de São Paulo Faculdade de Fonoaudiologia; Universidade Federal de São Paulo (UNIFESP); Centro de Estudos da Voz Setor de Laringe e VozDystonias are organic central motor processing disorders characterized by involuntary muscular contractions or incontrollable spasms induced by task-specific movements. Adduction laryngeal dystonias present with important speech impairments, with inappropriate spasms and abrupt voice breaks. The diagnosis is based on clinical features, evaluation by a speech therapist and transnasal fiber optic laryngoscopy. AIM: Our objective is to propose and evaluate a task-oriented transnasal fiber optic laryngoscopy protocol, which shows the spasms, and propose maneuvers that reduce or make them disappear, in order to facilitate the diagnosis. METHODS: transversal study. Analysis of the transnasal fiber optic laryngoscopy records of 15 patients with adductor laryngeal dystonia using the proposed protocol. RESULTS: most of the speech and non-vocal tasks allowed us to identify the spasms and reduce or make them disappear. We propose the exclusion of two of the maneuvers that don t bring new data to the evaluation. CONCLUSION: the protocol was useful for the evaluation of the patients, showing changes in muscle behavior in the structure under investigation.
- ItemAcesso aberto (Open Access)Distonia laríngea respiratória(ABORL-CCF Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial, 2003-10-01) Lebl, Mariana Dantas Aumond [UNIFESP]; De Biase, Noemi Grigoletto [UNIFESP]; Silveira, Paula Angélica L. [UNIFESP]; Pontes, Paulo Augusto de Lima [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Laryngeal Breathing Dystonia (LBD) is a rare disorder characterized by inappropriate adduction of the true vocal cords during inspiration, resulting in stridor and dispnea. However, sometimes it is difficult to recognize the underlying etiology of the stridor, specially in emergencial situations, and LBD may be occasionally misdiagnosed, which makes this disease perhaps more frequent than it has been taught. The diagnosis is further supported by the finding of dystonic features and by exclusion of other causes of paradoxical vocal cord motion. There has been no satisfactory treatment for the disease. Botulinum toxin type A (Botox®) injection into the thyreoarytenoid muscle has been shown to be very effective, but only few cases have been reported. The authors describe the clinical presentation of Laryngeal Breathing Dystonia in two patients with complaints of stridor. Evaluation by laryngoscopy revealed paradoxical vocal cord motion and malacia of the epiglottis. Treatment was attempted by injection of Botox® in the adductor muscles. In this article the diagnostic approach of this disease is evaluated in accordance to the earliest concepts on laryngeal dystonias. Based on the classification system for laryngeal dystonias presented by Koufman and Blabock, the authors propose the recognition of a new subtype of DLR.
- ItemSomente MetadadadosGlottic characteristics and voice complaint in the elderly(Mosby, Inc, 2005-03-01) Pontes, P.; Brasolotto, A.; Behlau, M.; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP); Inst Laringe; Ctr Estudos VozThis study evaluated the relationship between voice complaint and deviant vocal fold status with special regard to presbylarynx, in patients aged more than 60 years, with pharyngeal-laryngeal complaint. the material consisted of clinical histories and images obtained by laryngoscopies from protocols from the Larynx Institute-INLAR, São Paulo, Brazil, of 210 patients, 88 men and 122 women, aged more than 60 years, who had sought otorhinolaryngologic treatment. Indicative glottic characteristics of the presbylarynx, such as vocal fold bowing, prominence of vocal processes, and spindle-shaped glottic chink, were analyzed. the increase in mass, leukoplakia, and other vocal fold alterations, distinct from these two, grouped as miscellaneous, as well as the presence or absence of voice complaint were also analyzed. Vocal fold bowing, prominence of vocal processes, and spindle-shaped glottic chink showed a strong correlation among each other. the presence of presbylarynx was accompanied by less voice complaint than the presence of vocal fold mucosa alterations, which in turn are more common where an absence of presbylarynx exists.
- ItemSomente MetadadadosImportance of glottic configuration in the development of posterior laryngeal granuloma(Annals Publ Co, 2001-08-01) Pontes, Paulo [UNIFESP]; De Biase, Noemi Grigoletto [UNIFESP]; Kyrillos, Leny Cristina Rodrigues [UNIFESP]; Pontes, Antonio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Pontificia Univ CatolicaPosterior laryngeal granuloma is frequently related to 3 predisposing factors: vocal abuse, gastroesophageal reflux disease, and orotracheal intubation. It is strongly predominant in men and rare in women, except under postintubation circumstances, in which the incidence is higher in women. The aim of this study was to characterize laryngeal conformations for each sex that, whenever associated with different causes, may lead to the onset and particular location of granulomas, according to a main predisposing factor. Sixty-six subjects whose ages ranged from 18 to 73 years were studied. They were distributed into 4 groups according to the predominant cause of granuloma: intubation, vocal abuse, gastroesophageal reflux, and idiopathic causes. The larynx was evaluated during breathing, and the glottic proportion (GP) was measured. Glottic proportion is the mathematical ratio between the midsagittal dimension of the intermembranous region and that of the intercartilaginous region of the larynx during inhalation. Its measurement was feasible in 57 patients. The groups that had a causative factor other than laryngeal orotracheal intubation had GP values statistically similar to those of each other and to the control group of men, ie, close to 1.2. The postintubation group had GP values similar to the control group of women, ie, close to 1.0; this proportion protects the arytenoid region in women's larynges when there is effort during vocal production, but makes women susceptible to orotracheal postintubation granuloma.