Navegando por Navegando por Palavras-chave "transrepression"
Agora exibindo 1 - 1 de 1
Resultados por página
Opções de Ordenação
- ItemAcesso aberto (Open Access)Gene Expression Control by Glucocorticoid Receptors during Innate Immune Responses(Frontiers Media Sa, 2016) Xavier, Andre Machado [UNIFESP]; Anunciato, Aparecida Kataryna Olimpio [UNIFESP]; Rosenstock, Tatiana Rosado; Glezer, Isaias [UNIFESP]Glucocorticoids (GCs) are potent anti-inflammatory compounds that have been extensively used in clinical practice for several decades. GC's effects on inflammation are generally mediated through GC receptors (GRs). Signal transduction through these nuclear receptors leads to dramatic changes in gene expression programs in different cell types, typically due to GR binding to DNA or to transcription modulators. During the last decade, the view of GCs as exclusive anti-inflammatory molecules has been challenged. GR negative interference in pro-inflammatory gene expression was a landmark in terms of molecular mechanisms that suppress immune activity. In fact, GR can induce varied inhibitory molecules, including a negative regulator of Toll-like receptors pathway, or subject key transcription factors, such as NF-kappa B and AP-1, to a repressor mechanism. In contrast, the expression of some acute-phase proteins and other players of innate immunity generally requires GR signaling. Consequently, GRs must operate context-dependent inhibitory, permissive, or stimulatory effects on host defense signaling triggered by pathogens or tissue damage. This review aims to disclose how contradictory or comparable effects on inflammatory gene expression can depend on pharmacological approach (including selective GC receptor modulators