Navegando por Palavras-chave "target"

Agora exibindo 1 - 1 de 1
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    Expression of a cell death marker (clusterin) in muscle target fibers
    (Academia Brasileira de Neurologia - ABNEURO, 1993-09-01) Oliveira, Acary Souza Bulle [UNIFESP]; Corbo, Massimo; Duigou, Greg; Gabbai, Alberto Alain [UNIFESP]; Hays, Arthur P.; Universidade Federal de São Paulo (UNIFESP); Columbia University College of Physicians and Surgeons Department of Neurosurgery
    We report, for the first time, the expression of immunoractivity to clusterin in skeletal muscle. Clusterin, a protein probably related to the process of programmed cell death (apoptosis), was specifically very highly expressed in target fibers. All target fibers found in 50 muscle biopsy samples from a variety of neuromuscular disorders expressed a high concentration of clusterin in the middle of the targets. Clusterin was not expressed in any targetoid fibers or cores. Acute denervation, where targets are mostly seen, may be the beginning of apoptosis. Hence our findings support the concept that targets are harbingers of acute denervation.