Navegando por Palavras-chave "sudden unexpected death in epilepsy"

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    Could sudden cardiac death in epilepsy be related to the occurrence of thalamic dysfunction or anatomic change?
    (Academia Brasileira de Neurologia - ABNEURO, 2009-03-01) Scorza, Fulvio Alexandre [UNIFESP]; Calderazzo, Lineu [UNIFESP]; Albuquerque, Marly de [UNIFESP]; Arida, Ricardo Mario [UNIFESP]; Almeida, Antonio-Carlos G. de; Cavalheiro, Esper Abrão [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade Federal de São João Del Rei Departamento de Engenharia Biomédica
    Sudden unexpected death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of death in people with chronic epilepsy. Its physiopathology is still unknown; however, the most commonly suggested potential mechanisms involve cardiac or respiratory abnormalities. As the anatomical substrate of epileptic activity in the central nervous system (CNS) shows a direct relationship with cardiovascular alterations, this may suggests that patients with epilepsy associated with focal CNS lesions may be at particular risk of SUDEP. Currently, experimental and clinical data support an important role for thalamic nuclei in the behavioural manifestations, initiation and propagation of seizures. In view of the above findings, we purpose that SUDEP, at least in some cases, could be related to the occurrence of thalamic dysfunction or anatomic change.
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    Fish Oil Supplementation Reduces Heart Levels of Interleukin-6 in Rats with Chronic Inflammation due to Epilepsy
    (Frontiers Media Sa, 2017) Nejm, Mariana Bocca [UNIFESP]; Abou Haidar, Andre [UNIFESP]; Hirata, Aparecida Emiko [UNIFESP]; Oyama, Lila Missae [UNIFESP]; de Almeida, Antonio-Carlos Guimaraes; Cysneiros, Roberta Monterazzo; Cavalheiro, Esper Abrao [UNIFESP]; Scorza, Carla Alessandra [UNIFESP]; Scorza, Fulvio Alexandre [UNIFESP]
    Sudden unexpected death in epilepsy (SUDEP) is a major cause of premature death related to epilepsy. The causes of SUDEP remain unknown, but cardiac arrhythmias and asphyxia have been suggested as a major mechanism of this event. Inflammation has been implicated in the pathogenesis of both epilepsy and ventricular arrhythmia, with interleukin-6 (IL-6) being recognized as a crucial orchestrator of inflammatory states. Our group previously reported that levels of IL-6 were increased in the hearts of epileptic rats. In this scenario, anti-inflammatory actions are among the beneficial effects of fish oil dietary supplementation. This investigation revealed that elevated levels of IL-6 in the heart were markedly reduced in epileptic rats that were treated in the long-term with fish oil, suggesting protective anti-inflammatory actions against dangerously high levels of IL-6. Based on these findings, our results suggest beneficial effects of long-term intake of fish oil in reducing the inflammation associated with chronic epilepsy.