Navegando por Palavras-chave "strength"

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    Scaling skeletal muscle function to mass in patients with moderate-to-severe COPD
    (Springer, 2006-11-01) Malaguti, Carla; Nery, Luiz E.; Dal Corso, Simone; Napolis, Lara; De Fuccio, Marcelo Bicalho; Lazaretti-Castro, Marise [UNIFESP]; Neder, José Alberto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); UNINOVE
    Skeletal muscle performance and muscle mass are commonly reduced in patients with advanced chronic obstructive pulmonary disease (COPD). It is currently unclear, however, whether negative changes in muscle structure and function are proportionately related to each other in these patients. in a cross-sectional study, 39 patients (post-bronchodilator FEV1 = 49.7 +/- 15.5% pred) and 17 controls were submitted to knee isokinetic dynamometry [peak torque (PT), isometric strength (IS), and total work (TW)] and dual energy X-ray absorptiometry for the evaluation of leg muscle mass (LMM). Muscle function (F) was normalised for LMM by using ratio standards (F center dot LMM-1), power function ratios (F center dot LMM-b, where b is usually not equal 1), and analysis of covariance (ANCOVA). Patients with COPD presented with reduced PT, IS, TW, and LMM as compared to controls: there were significant linear correlations among these variables in both groups (P < 0.05). Ratio standards of PT center dot LMM-1 and TW center dot LMM-1 were, on average, 14% lower in patients than controls (P < 0.01). the coefficients for allometric correction of IS and TW were significantly higher in patients as compared to controls (0.975 vs. 0.603 and 1.471 vs. 0.824, respectively, P < 0.05), i.e. more LMM was needed to generate a given functional output in patients than normal subjects. in addition, adjusted means of muscle function variables by ANCOVA were 11-18% lower for patients than controls with LMM as the covariate (P < 0.05). We conclude that factors other than simple atrophy (i.e. mass-independent mechanisms) might play a role in explaining the COPD-related skeletal muscle dysfunction.
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    Screening for muscle wasting and dysfunction in patients with chronic kidney disease
    (Nature Publishing Group, 2016) Carrero, Juan J.; Johansen, Kirsten L.; Lindholm, Bengt; Stenvinkel, Peter; Cuppari, Lilian [UNIFESP]; Avesani, Carla M.
    Skeletal muscle mass and muscle function are negatively affected by a variety of conditions inherent to chronic kidney disease (CKD) and to dialysis treatment. Skeletal muscle mass and function serve as indicators of the nutritional and clinical state of CKD patients, and low values or derangements over time are strong predictors of poor patient outcomes. However, muscle size and function can be affected by different factors, may decline at different rates, and may have different patient implications. Therefore, operational definitions of frailty and sarcopenia have emerged to encompass these 2 dimensions of muscle health, i.e., size and functionality. The aim of this review is to appraise available methods for assessment of muscle mass and functionality, with an emphasis on their accuracy in the setting of CKD patients. We then discuss the selection of reference cutoffs for defining conditions of muscle wasting and dysfunction. Finally, we review definitions applied in studies addressing sarcopenia and frailty in CKD patients and discuss their applicability for diagnosis and monitoring.
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    Skeletal muscle structure and function in response to electrical stimulation in moderately impaired COPD patients
    (W B Saunders Co Ltd, 2007-06-01) Dal Corso, Simone [UNIFESP]; Nápolis, Lara Maris [UNIFESP]; Malaguti, Carla [UNIFESP]; Gimenes, Ana Cristina Oliveira [UNIFESP]; Albuquerque, André Luis Pereira de; Nogueira, Cristiano Rabelo [UNIFESP]; De Fuccio, Marcelo Bicalho; Pereira, Roberto Dias Batista [UNIFESP]; Oliveira, Acary Souza Bulle [UNIFESP]; McFarlane, Niall; Nery, Luiz Eduardo [UNIFESP]; Neder, Jose Alberto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Univ Glasgow
    Study objective: To determine the structural and functional consequences of high-frequency neuromuscular electrical stimulation (hf-NMES) in a group of moderately impaired outpatients with chronic obstructive pulmonary disease (COPD).Design: A prospective, cross-over randomized trial.Setting: An university-based, tertiary center.Patients and materials: Seventeen patients (FEV1 = 49.6 +/- 13.4% predicted, Medical Research Council dyspnoea grades II-III) underwent 6-weeks hf-NMES (50 Hz) and sham stimulation of the quadriceps femoris in a randomized, cross-over design. Knee strength was measured by isokinetic dynamometry (peak torque) and leg muscle mass (LMM) by DEXA; in addition, median cross-sectional area (CSA) of type I and fibres and capillary-fibre ratio were evaluated in the vastus lateralis. the 6-min walking distance (6MWD) was also determined.