Navegando por Palavras-chave "skull"

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    Avaliação histomorfométrica e imunoistoquímica do uso da hidroxiapatia manométrica em defeitos ósseos na calota craniana de ratos
    (Universidade Federal de São Paulo (UNIFESP), 2016-06-29) Faria, Marcio Antonio [UNIFESP]; Simoes, Manuel de Jesus Simoes [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Currently it is considered a challenge to surgical reconstruction of bone defects created by trauma and degenerative diseases. It is eventually necessary to use autogenous bone or other bone substitute biomaterials, performing procedures grafts and transplants. As part of these biomaterials, contains the hydroxyapatites (HA), which have shown promising for behaving biocompatible way. However, it is known that the size of the HA particles is important in bone healing process, once the biomaterial should be reabsorbed to make room for the bone tissue. In this context, the hydroxyapatite nanometer (nHA) has a promising role in the healing process of the bone tissue because of their small size and approach the size of the natural HA of bone crystals. The objective of this study was to evaluate the effect of nHA paste (ReproBone ®) in bone defects created in the skull of Wistar rats after 7, 14 and 21 days, by histomorphometric and immunohistochemical analysis for VEGFA. The nHA was implanted in calvarial defects in the test group while the control group defects were filled only with blood clot. The animals were divided into 6 groups: GI (ctrl 7 days), GII (ctrl 14 days), GIII (ctrl 21 days), GIV (test 7 days), GV (trial 14 days), GVI (test 21 days). After surgery, the animals were euthanized and the calvaria removed for histological and immunohistochemical processing. The results showed that the test groups increased formation of bone tissue compared to control groups at 21 days was the total closure of the bone defect in the test group. There was a greater reactivity to Vegf in connective tissue region and the periphery of the newly formed bone in the test groups compared to control groups. It follows from the data obtained that nHA accelerates bone regeneration process at all times 7, 14 and 21 days and that its use could promote full healing of a critical defect in bone tissue.
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    Craniofacial asymmetry in development: An anatomical study
    (E H Angle Education Research Foundation, Inc, 2003-08-01) Rossi, Marcelle; Ribeiro, Eduardo [UNIFESP]; Smith, Ricardo Luiz [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Bahiana Sch Dent
    The purpose of this study was to evaluate the occurrence of craniofacial asymmetries in four areas of human skulls of various age groups to test the hypothesis that there is craniofacial symmetry before the chewing habit is established. The data were obtained from 95 skulls of fetuses, infants, children, and adults, from the collection of Federal University of Sao Paulo. The following measurements were taken on each skull with a digital caliper: from the infraorbital foramen to the anterior nasal spine (IOF); from the greater palatine foramen to the posterior nasal spine (GPF); from the spinous foramen to the basion (SF); and from the spinous foramen to the zygomatic arch (ZA). On different occasions, each measurement was taken three times on both sides of the skull in random order. The mean of the right-side measurements were subtracted from the mean of the left-side measurements, and the differences were transformed into percentages. Comparisons were made by analysis of variance. The presence of cranial asymmetry was statistically significant throughout the whole sample. The minimum value found was 2.8% and the maximum 6.5%. All age groups presented the same degree of asymmetry of distances IOF, GPF, and SE The group of infants presented a higher degree of asymmetry on distance ZA, followed by the groups of fetuses, children, and adults. This study confirmed statistically significant craniofacial asymmetry in fetuses and infants (before dentition). Therefore, the hypothesis that craniofacial asymmetry only appears after establishment of the chewing habit was not supported.