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    Avaliação de fatores clínicos, laboratoriais e ultrassonográficos preditores de malignidade em nódulos tiroidianos
    (Sociedade Brasileira de Endocrinologia e Metabologia, 2011-02-01) Rio, Ana Luiza Silva [UNIFESP]; Biscolla, Rosa Paula Mello [UNIFESP]; Andreoni, Danielle Macellaro [UNIFESP]; Camacho, Cléber Pinto [UNIFESP]; Nakabashi, Cláudia Cristina Doimo [UNIFESP]; Mamone, Maria da Conceição de Oliveira Carneiro [UNIFESP]; Ikejiri, Elza Setsuku [UNIFESP]; Matsumura, Luiza Kimiko [UNIFESP]; Hidal, Jairo Tabacow [UNIFESP]; Maciel, Rui Monteiro de Barros [UNIFESP]; Furlanetto, Reinaldo Perrone [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Instituto Israelita de Ensino e Pesquisa Albert Einstein Centro de Doenças Tiroidianas; Fleury Medicina e Saúde
    OBJECTIVE: To evaluate the risk of malignancy in thyroid nodules through clinical, laboratory, ultrasonographic and cytological aspects. PATIENTS AND METHODS: 741 nodules of 407 patients. RESULTS: The cytology was benign (60,5%), indeterminate (23,3%), malignant (8,3%) or nondiagnostic (7,6%). The prevalence of cancer in indeterminate citology was 18,5% (16% in follicular lesions, 44% in suspicious). The diagnosis of malignancy was 17,2% (n = 70). The frequency of cancer in women (15,2%) was lower than in men (27,9%). There was an inverse relation between age and cancer risk. There was no statistical significance in the prevalence of cancer according to number, size of nodules or TSH levels. Hypoechogenicity and microcalcifications on ultrasound were risk factors. CONCLUSION: The risk of malignancy was higher in men, hypoechoic nodules, with microcalcifications and was inversely related to age. The TSH level was not an independent factor predictive of malignancy.