Navegando por Palavras-chave "rapid-onset behavioral sensitization"

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    Amphetamine-induced rapid-onset sensitization: Role of novelty, conditioning and behavioral parameters
    (Elsevier B.V., 2006-04-01) Nascimento Alvarez, J. do; Fukushiro, D. F.; Obara Tatsu, J. A.; Pereira de Carvalho, E.; Castro Gandolfi, A. C. de; Tsuchiya, J. B.; Carrara-Nascimento, P. F.; Lima, M. L.; Gentil Bellot, R.; Frussa-Filho, R.; Universidade Federal de São Paulo (UNIFESP); Univ Metodista São Paulo
    Background: Environmental factors may modulate sensitization to the locomotor-activating effects of psychostimulants. in addition, some parameters of locomotor activity seem to be more sensitive to detect cocaine-induced behavioral sensitization. We examined how novelty and conditioning can modulate a previously described rapid-onset type of behavioral sensitization to amphetamine (AMP) in mice, using total, peripheral and central open-field locomotion frequencies as experimental parameters.Methods: in the first experiment, mice received an ip injection of saline (SAL) or 5.0 mg/kg AMP paired or not with the open-field or in their home-cages. Four hours later, all the animals received an ip SAL challenge injection and, 15 min later, were observed in the open-field for quantification of total, peripheral and central locomotion frequencies. the second experiment had a similar protocol, except that mice received a challenge injection of 1.5 mg/kg AMP.Results: the priming AMP injection significantly increased all the parameters of locomotion of SAL-challenged mice firstly exposed to or previously paired (but not impaired) with the open-field. AMP priming injection enhanced total and peripheral locomotion of all AMP-challenged mice but only increased central locomotion of mice submitted to novelty or environmental conditioning.Conclusion: Our results showed: 1) the development of an AMP-induced rapid-onset sensitization to novelty and rapid-onset environmental conditioning in mice, 2) the potentiation of the AMP-induced rapid-onset sensitization to an AMP challenge injection by novelty and environmental conditioning and 3) the importance of measuring different locomotor activity parameters in behavioral sensitization experiments. (c) 2006 Elsevier Inc. All rights reserved.
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    Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil
    (Frontiers Media Sa, 2016) Wuo-Silva, Raphael [UNIFESP]; Fukushiro, Daniela Fukue [UNIFESP]; Hollais, André Willian [UNIFESP]; Santos-Baldaia, Renan [UNIFESP]; Mari-Kawamoto, Elisa [UNIFESP]; Berro, Laís Fernanda [UNIFESP]; Yokoyama, Thais Suemi [UNIFESP]; Lopes-Silva, Leonardo Brito [UNIFESP]; Bizerra, Carolina Souza [UNIFESP]; Procopio-Souza, Roberta [UNIFESP]; Hashiguchi, Debora [UNIFESP]; Figueiredo, Lilian A. [UNIFESP]; Costa, Jose L.; Frussa-Filho, Roberto [UNIFESP]; Longo, Beatriz Monteiro [UNIFESP]
    There is substantial controversy about the addictive potential of modafinil, a wake promoting drug used to treat narcolepsy, proposed as pharmacotherapy for cocaine abuse, and used indiscriminately by healthy individuals due to its positive effects on arousal and cognition. The rapid-onset type of behavioral sensitization (i.e., a type of sensitization that develops within a few hours from the drug priming administration) has been emerged as a valuable tool to study binge-like patterns of drug abuse and the neuroplastic changes that occur quickly after drug administration that ultimately lead to drug abuse. Our aim was to investigate the possible development of rapid-onset behavioral sensitization to modafinil and bidirectional rapid-onset cross sensitization with cocaine in male Swiss mice. A priming injection of a high dose of modafinil (64 mg/kg) induced rapid-onset behavioral sensitization to challenge injections of modafinil at the doses of 16, 32, and 64 mg/kg, administered 4 h later. Furthermore, rapid-onset cross-sensitization was developed between modafinil and cocaine (64 mg/kg modafinil and 20 mg/kg cocaine), in a bidirectional way. These results were not due to residual levels of modafinil as the behavioral effects of the priming injection of modafinil were no longer present and modafinil plasma concentration was reduced at 4 h post-administration. Taken together, the present findings provide preclinical evidence that modafinil can be reinforcing per se and can enhance the reinforcing effects of stimulants like cocaine within hours after administration.