Navegando por Palavras-chave "preterm delivery"
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- ItemSomente MetadadadosCervical gland area as an ultrasonographic marker for preterm delivery(Elsevier B.V., 2006-06-01) Pires, C. R.; Moron, A. F.; Mattar, Rosiane [UNIFESP]; Diniz, ALD; Andrade, SGA; Bussamra, LCS; Universidade Federal de São Paulo (UNIFESP)Objective: To assess the association between spontaneous preterm delivery (SPTD) in the general population and the measurement of the cervix length, cervical funneling, and absence of the cervical gland area (CGA). Method: A prospective cohort of 338 women carrying uncomplicated pregnancies was evaluated by transvaginal sonography between 21 and 24 weeks' gestation. Results: Measurement of cervical length with less than 20 mm and the presence of cervical funneling presented a statistically significant association with SPTD before 35 weeks. the nondetection of CGA demonstrated a strong association with SPTD before 37 weeks' (p < 0.001; OR=194.5) and before 35 weeks' gestation (p < 0.001; OR=129.6). the multiple logistic regression analysis suggested the non-detection of CGA as the only variable to reveal statistically significance association with SPTD. Conclusion: the results seem to indicate that the absence of CGA can be a new and important ultrasound marker for SPTD, to be confirmed by future multicenter investigations. (c) 2005 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
- ItemSomente MetadadadosCongenital heart disease and adverse perinatal outcome in fetuses with confirmed isolated single functioning umbilical artery(Informa Healthcare, 2015-01-01) Araujo Junior, E. [UNIFESP]; Palma-Dias, R.; Martins, W. P.; Reidy, K.; Costa, F. da Silva; Royal Womens Hosp; Univ Melbourne; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)To examine the association between isolated single umbilical artery (SUA) and congenital heart disease/adverse perinatal outcome in an Australian tertiary centre. the study population was comprised of fetuses diagnosed with SUA at the mid-trimester scan between May 2003 and March 2009 during detailed ultrasound examination at the Royal Women's Hospital Melbourne, Australia. Colour Doppler was used to visualise the umbilical arteries adjacent to the fetal bladder and in a section of a free loop of cord. the diagnosis of SUA was confirmed on histopathology examination of the placenta and umbilical cord. Monochorionic twins, fetuses with chromosomal abnormalities or concurrent extracardiac anomalies were excluded from the study. A total of 261 fetuses with SUA were identified in the study period and 146 (59%) cases were isolated; no chromosomal or extracardiac abnormalities were present. Complete data were available in 104/146 pregnancies (71.2%). the mean gestational age at diagnosis was 21 weeks. A cardiac anomaly was detected in 19 of these fetuses (13.0%): six hypoplastic left heart syndromes; three coarctations of the aorta; two tetralogies of Fallot; two hypoplastic right heart syndromes; two pulmonary atresia/stenosis; one absent ductus venosus with cardiomegaly; one left isomerism; one right isomerism and one transposition of the great arteries. Fetal growth restriction was present in 9.8% (10) and preterm delivery before 34 weeks occurred in nine cases (8.7%). Our study has shown that isolated SUA is associated with cardiac anomalies, but is not associated with increased frequency of FGR and preterm delivery before 34 weeks.
- ItemSomente MetadadadosFetal fibronectin as a predictor of preterm delivery in twin gestations(Elsevier B.V., 1998-08-01) Oliveira, T.; Souza, E. de; Mariani-Neto, C.; Camano, L.; Hosp Maternidade Leonor Mendes Barros; Universidade Federal de São Paulo (UNIFESP)Objective: To evaluate fetal fibronectin as a predictor of premature delivery in twin pregnancies. Method: Cervicovaginal secretions were obtained from 52 pregnant women with twin pregnancies between 24 and 34 weeks of gestation. the secretions were analyzed to detect the presence of fetal fibronectin by immediate-reading membrane test. the correlation between the presence of fetal fibronectin and preterm birth was evaluated. in addition, cervical dilatation and effacement were evaluated with each sampling. Result: the sensitivity, specificity, positive predictive value and negative predictive value to predict preterm delivery were 89.3, 50.0, 67.6, and 80.0%, respectively. A positive fetal fibronectin result was associated with a relative risk (RR) for preterm birth of 3.4 (95% CI, 1.2-9.5). A positive fetal fibronectin test associated with cervical dilatation or effacement increased the RR for preterm birth to 4.3 and 7.7, respectively, when compared with those with negative test and without cervical dilatation and effacement. Conclusion: Fetal fibronectin in the cervicovaginal secretions of patients with twin pregnancies is a sensitive predictor of preterm delivery. However, because of its low specificity, the fetal fibronectin test should be evaluated along with cervical changes for better identification of twins likely to develop preterm labor. (C) 1998 International Federation of Gynecology and Obstetrics.
- ItemSomente MetadadadosProteomic Biomarkers for Spontaneous Preterm Birth: A Systematic Review of the Literature(Sage Publications Inc, 2014-03-01) Kacerovsky, Marian; Lenco, Juraj; Musilova, Ivana; Tambor, Vojtech; Lamont, Ronald; Torloni, Maria Regina [UNIFESP]; Menon, Ramkumar; PREBIC Biomarker Working Grp; Univ Hosp Hradec Kralove; Charles Univ Prague; Univ Def; Hosp Pardubice; Odense Univ Hosp; Universidade Federal de São Paulo (UNIFESP); Univ Texas Med BranchThis review aimed to identify, synthesize, and analyze the findings of studies on proteomic biomarkers for spontaneous preterm birth (PTB). Three electronic databases (Medline, Embase, and Scopus) were searched for studies in any language reporting the use of proteomic biomarkers for PTB published between January 1994 and December 2012. Retrieved citations were screened, and relevant studies were selected for full-text reading, in triplicate. the search yielded 529 citations, 51 were selected for full-text reading and 8 studies were included in the review. A total of 64 dysregulated proteins were reported. Only 14-3-3 protein sigma, annexin A5, protein S100-A8, protein S100-A12, and inter--trypsin inhibitor heavy chain H4 were reported in more than 1 study, but results could not be combined due to heterogeneity in type of sample and analytical platform. in conclusion, according to the existing literature, there are no specific proteomic biomarkers capable of accurately predicting PTB.