Navegando por Palavras-chave "polissacarídeo"

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    Resposta a antígenos polissacarídicos em pacientes com ataxia-telangiectasia
    (Sociedade Brasileira de Pediatria, 2006-04-01) Guerra-Maranhão, Maria Cristina [UNIFESP]; Costa-Carvalho, Beatriz Tavares [UNIFESP]; Nudelman, Victor [UNIFESP]; Barros-Nunes, Patrícia [UNIFESP]; Carneiro-Sampaio, Magda Maria Sales; Arslanian, Cristina; Nagao-Dias, Aparecida Tiemi [UNIFESP]; Solé, Dirceu [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Hospital Albert Einstein; Universidade de São Paulo (USP); Univ. de São Paulo Instituto de Ciências Biomédicas Laboratório de Imunologia de Mucosas; Universidade Federal do Ceará Faculdade de Farmácia Departamento de Análises Clínicas e Toxicológicas
    OBJECTIVE: To analyze the production of antibodies to polysaccharide antigens in patients with ataxia-telangiectasia. PATIENTS AND METHODS: We used the ELISA technique to measure the levels of IgG antibodies to serotypes 1, 3, 5, 6B, 9V and 14 of Streptococcus pneumoniae in 14 patients with ataxia-telangiectasia before and after immunization with 23-valent polysaccharide vaccine. Adequate response to individual polysaccharide can be defined as a postimmunization antibody titer equal to or greater than 1.3 µg/ml or as a minimum fourfold increase over the baseline (preimmunization) value. RESULTS: Six (43%) patients showed an absent response to all serotypes analyzed. Four patients showed adequate response to only one serotype, one patient to two serotypes, two patients to three serotypes and only one patient to four out of six serotypes analyzed. No patient had adequate response to all serotypes tested. Postimmunization pneumococcus IgG levels were higher than preimmunization levels to all serotypes analyzed, except for serotype 3. In spite of this, the mean postimmunization levels were lower than 1.3 µg/ml in all serotypes, except for serotype 14. Mean increment was less than four in all serotypes analyzed. CONCLUSION: Our results suggest that patients with ataxia-telangiectasia are at a high risk of having an impaired response to pneumococcus, which may be one of the causes of recurrent sinopulmonary infections in these patients.