Navegando por Palavras-chave "pharmacodynamics"

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    Pharmacodynamics of the Novel Antifungal Agent F901318 for Acute Sinopulmonary Aspergillosis Caused by Aspergillus flavus
    (Oxford Univ Press Inc, 2018) Negri, Clara Ezequiel [UNIFESP]; Johnson, Adam; McEntee, Laura; Box, Helen; Whalley, Sarah; Schwartz, Julie A.; Ramos-Martin, V.; Livermore, Joanne; Kolamunnage-Dona, Ruwanthi; Colombo, Arnaldo Lopes [UNIFESP]; Hope, William W.
    Background. Aspergillus flavus is one of the most common agents of invasive aspergillosis and is associated with high mortality. The orotomides are a new class of antifungal agents with a novel mechanism of action. An understanding of the pharmacodynamics (PD) of the lead compound F901318 is required to plan safe and effective regimens for clinical use. Methods. The pharmacokinetics (PK) and PD of F901318 were evaluated by developing new in vitro and in vivo models of invasive fungal sinusitis. Galactomannan was used as a pharmacodynamic endpoint in all models. Mathematical PK-PD models were used to describe dose-exposure-response relationships. Results. F901318 minimum inhibitory concentrations (MICs) ranged from 0.015 to 0.06 mg/L. F901318 induced a concentration-dependent decline in galactomannan. In the in vitro model, a minimum concentration: MIC of 10 resulted in suppression of galactomannan
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    PHARMACOKINETICS and PHARMACODYNAMICS of ANTIMICROBIAL DRUGS in INTENSIVE CARE UNIT PATIENTS
    (Lippincott Williams & Wilkins, 2013-05-01) Macedo, Rodrigo Spineli [UNIFESP]; Onita, Julio Henrique [UNIFESP]; Wille, Marcos Paulo [UNIFESP]; Furtado, Guilherme Henrique Campos [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Inappropriate use of antimicrobial drugs is responsible for therapeutic failures, increased mortality rates, and the emergence of resistance. Antimicrobial activity is determined by intrinsic pharmacokinetics/pharmacodynamics concepts. in critically ill patients, an inappropriate dosing regimen can be caused by the inability of an antimicrobial drug to reach adequate concentrations at the infection site owing to alterations in the drug's pharmacokinetics caused by pathophysiological changes. Understanding these concepts and changes in PK-PD parameters that occur in intensive care unit patients is crucial for the optimization of antimicrobial therapy in these patients.