Navegando por Palavras-chave "pediatric rheumatology"

Agora exibindo 1 - 1 de 1
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus
    (Oxford Univ Press, 2016) Pereira, Kaline Medeiros Costa [UNIFESP]; Faria, Atila Granados Afonso de [UNIFESP]; Liphaus, Bernadete L.; Jesus, Adriana A.; Silva, Clovis A.; Carneiro-Sampaio, Magda; Andrade, Luiz Eduardo Coelho [UNIFESP]
    Objective. Complete deficiency of Complement C4 component is a strong genetic risk factor for SLE. C4 is encoded by two different genes, C4A and C4B, which show considerable gene copy number (GCN) variation. This study investigates the association of total C4, C4A and C4B GCN with JSLE. Methods. Ninety JSLE patients, 170 adult-onset SLE (aSLE) patients and 200 healthy individuals were evaluated for C4A and C4B GCN by quantitative real-time PCR. Results. JSLE patients had lower GCN for C4A (mean = 1.7