Navegando por Palavras-chave "outcome measures"

Agora exibindo 1 - 2 de 2
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Comparing the burden of illness of haemophilia between resource-constrained and unconstrained countries: the Sao Paulo-Toronto Hemophilia Study
    (Wiley, 2017) Carneiro, J. D. A.; Blanchette, V.; Ozelo, M. C.; Antunes, S. V. [UNIFESP]; Villaca, P. R.; Young, N. L.; Castro, D.; Brandao, L. R.; Carcao, M.; Abad, A.; Feldman, B. M.
    Introduction: Although the regular replacement of clotting factor concentrates (prophylaxis) has been well established as the standard of care for severe haemophilia, the high cost of factor concentrates has limited access to prophylaxis in countries with under-developed or developing economies. Aims: We studied the health gap that could be addressed by providing unlimited access to clotting factor concentrates with implementation of long-term prophylaxis initiated from an early age in life. Methods: We performed a cross-sectional study of a random, representative sample of boys with moderate and severe haemophilia at three haemophilia treatment centres in Sao Paulo, Brazil, and one centre in Toronto, Canada. Results: Canadian subjects were more often treated with prophylaxis, and began treatment at an earlier age. Fewer Canadian subjects had bleeds within the preceding 6 months (19 vs. 34, P = 0.003). Canadian subjects had lower (better) Pettersson radiographic scores (1.5 vs. 6.0, P = 0.0016), lower (better) Hemophilia Joint Health Scores (5.5 vs. 10.5, P = 0.0038), higher (better) Activity Scale for Kids scores (96.6 vs. 92.0, P = 0.033), more time spent in vigorous activity, and higher (better) social participation scores. Conclusions: Our findings suggest that increasing access to clotting factor concentrates for young boys with severe haemophilia is a global imperative.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Comparison of the responsiveness of the Brazilian version of the Western Ontario Rotator Cuff Index (WORC) with DASH, UCLA and SF-36 in patients with rotator cuff disorders
    (Clinical & Exper Rheumatology, 2009-09-01) Lopes, Andréa Diniz [UNIFESP]; Ciconelli, Rozana Mesquita [UNIFESP]; Carrera, Eduardo Frota [UNIFESP]; Griffin, S.; Faloppa, Flávio [UNIFESP]; Reis, Fernando Baldy dos [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Univ Western Ontario
    ObjectiveTo investigate the responsiveness of the Brazilian version of the Western Ontario Rotator Cuff Index (WORC) and compare it with the Disabilities of At-tit, Shoulder and Hand questionnaire (DASH), the University of California Los Angeles Shoulder Rating Scale (UCLA), and the Short-Form 36 questionnaire (SF-36) in patients with rotator cliff disorders.MethodsThe four questionnaires were administered to 30 patients tit baseline and 3 months after treatment (physiotherapy or surgery). The patients were divided into two groups: those who improved after treatment (n=20) and those who did not (n=10) based oil an anchor-based strategy to distinguish between the two groups and assess responsiveness. The t-test, the t-value of the paired t-test, the effect size (ES), and the standardized response mean (SRM) were calculated.ResultsAll four questionnaires registered statistically significant changes (p<0.05) in the improved group between baseline and 3 months after treatment, and no changes in patients who did not improve. All four instruments showed higher ES and SRM values for the patients who improved than those who did not. WORC registered moderate to high ES and SRM values for the improved group, (is did the UCLA and DASH. The ES and SRM values Measured by the SF-36 ranged from small to large, the physical subscales being more responsive than the other subscales.ConclusionThe Brazilian version of the WORC (like UCLA, DASH and SF-36 physical subscales) proved responsive to change and suitable for use in the short-term follow-up of patients after rotator cuff interventions.