Navegando por Palavras-chave "osso"
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- ItemAcesso aberto (Open Access)Aspectos moleculares dos esteroides sexuais sobre a cartilagem e os ossos(Associação Médica Brasileira, 2012-08-01) Wolff, Roberta Bastos [UNIFESP]; Gomes, Regina Célia Teixeira [UNIFESP]; Verna, Carina [UNIFESP]; Maioral, Gabriela Carolina Carozi Cristofani [UNIFESP]; Rampazo, Thaís Cristina [UNIFESP]; Simões, Ricardo Santos [UNIFESP]; Baracat, Edmund Chada [UNIFESP]; Soares Júnior, José Maria [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)In Brazil, the increase in the reported cases of degenerative diseases of articular cartilage is 20% per year, meaning that 200,000 Brazilians develop degenerative joint diseases every year, which have a negative impact on bone mass. This study shows evidence that hormone production of sexual steroids (estrogens, progestogens, and androgens) have an influence on cartilage quality, as well as on bone mass. Therefore, this review aimed to analyze literature data on the molecular and genic action of sexual steroids on hyaline cartilage and bone physiology, as well as osteoarthritis interference on the quality of these structures.
- ItemSomente MetadadadosAvaliação histomorfométrica e imunoistoquímica do uso da hidroxiapatia manométrica em defeitos ósseos na calota craniana de ratos(Universidade Federal de São Paulo (UNIFESP), 2016-06-29) Faria, Marcio Antonio [UNIFESP]; Simoes, Manuel de Jesus Simoes [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Currently it is considered a challenge to surgical reconstruction of bone defects created by trauma and degenerative diseases. It is eventually necessary to use autogenous bone or other bone substitute biomaterials, performing procedures grafts and transplants. As part of these biomaterials, contains the hydroxyapatites (HA), which have shown promising for behaving biocompatible way. However, it is known that the size of the HA particles is important in bone healing process, once the biomaterial should be reabsorbed to make room for the bone tissue. In this context, the hydroxyapatite nanometer (nHA) has a promising role in the healing process of the bone tissue because of their small size and approach the size of the natural HA of bone crystals. The objective of this study was to evaluate the effect of nHA paste (ReproBone ®) in bone defects created in the skull of Wistar rats after 7, 14 and 21 days, by histomorphometric and immunohistochemical analysis for VEGFA. The nHA was implanted in calvarial defects in the test group while the control group defects were filled only with blood clot. The animals were divided into 6 groups: GI (ctrl 7 days), GII (ctrl 14 days), GIII (ctrl 21 days), GIV (test 7 days), GV (trial 14 days), GVI (test 21 days). After surgery, the animals were euthanized and the calvaria removed for histological and immunohistochemical processing. The results showed that the test groups increased formation of bone tissue compared to control groups at 21 days was the total closure of the bone defect in the test group. There was a greater reactivity to Vegf in connective tissue region and the periphery of the newly formed bone in the test groups compared to control groups. It follows from the data obtained that nHA accelerates bone regeneration process at all times 7, 14 and 21 days and that its use could promote full healing of a critical defect in bone tissue.
- ItemAcesso aberto (Open Access)Effects of cigarette smoke inhalation and coffee consumption on bone formation and osseous integration of hydroxyapatite implant(Instituto Internacional de Ecologia, 2013-02-01) Andrade, Ana R.; Sant'ana, Dcm.; Mendes Junior, Ja.; Moreira, Maria Eliza Castro; Pires, Gc.; Santos, Mp.; Fernandes, Geraldo Jose Medeiros [UNIFESP]; Nakagaki, Wilson Romero; Garcia, Jad.; Lima, Cc.; Soares, Ea.; Universidade José do Rosário Vellano; Universidade Federal de São Paulo (UNIFESP); Universidade Federal de Alfenas; Universidade Estadual de Campinas (UNICAMP); Universidade José do Rosário Vellano Faculdade de MedicinaThe present study aims to assess the effects of cigarette smoke inhalation and/or coffee consumption on bone formation and osseous integration of a dense hydroxyapatite (DHA) implant in rats. For this study, 20 male rats were divided into four groups (n = 5): CT (control) group, CE (coffee) group, CI (cigarette) group and CC (coffee + cigarette) group. During 16 weeks, animals in the CI group were exposed to cigarette smoke inhalation equivalent to 6 cigarettes per day; specimens in the CE group drank coffee as liquid diet; and rats in the CC group were submitted to both substances. In the 6th week a 5 mm slit in the parietal bone and a 4 mm slit in the tibia were performed on the left side: the former was left open while the latter received a DHA implant. As soon as surgeries were finished, the animals returned to their original protocols and after 10 weeks of exposure they were euthanised (ethically sacrificed) and the mentioned bones collected for histological processing. Data showed that exposure to cigarette smoke inhalation and coffee consumption did not interfere in weight gain and that solid and liquid diet consumption was satisfactory. Rats in the CC group showed a decrease in bone neoformation around the tibial DHA implant (31.8 ± 2.8) as well as in bone formation in the parietal slit (28.6 ± 2.2). On their own, cigarette smoke inhalation or coffee consumption also led to diminished bone neoformation around the implant and delayed the bone repair process in relation to the CT group. However, reduction in the bone repair process was accentuated with exposure to both cigarette smoke inhalation and coffee consumption in this study.