Navegando por Palavras-chave "nerve graft"

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    Nerve Regeneration: Is There an Alternative to Nervous Graft?
    (Thieme Medical Publ Inc, 2014-11-01) Sabongi, Rodrigo Guerra [UNIFESP]; Lucas Martins de Rizzo, Luiz Augusto [UNIFESP]; Fernandes, Marcela [UNIFESP]; Valente, Sandra Gomes [UNIFESP]; Gomes dos Santos, Joao Baptista [UNIFESP]; Faloppa, Flavio [UNIFESP]; Leite, Vilnei Mattioli [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Background in nerve injury with nervous gap, no restitution method was found better than the autograft, however, it has the disadvantage of damaging a normal nerve to be used as a graft. Platelet-rich plasma (PRP) is a possible filler material for vein grafts used as conduits for nerve regeneration, preventing its collapse, and providing growth factors and osteoconductive proteins.Methods Isogenic rats were randomly divided into three groups. They received nerve autografts (GRF), PRP-containing vein grafts or a sham operation. Outcomes were evaluated by the sciatic functional index (SFI), morphometric, and morphologic analyses of the nerve distal to the lesion, and the number of spinal cord motoneurons positive for retrograde Fluoro-Gold (Santa Cruz Biotechnology, Inc., Dallas, TX) tracer.Results the PRP and GRF groups had lower SFI values than the control animals throughout the postoperative period. the SFI was significantly higher in the PRP group than the GRF group at 90 days postoperatively (p = 0.011). Fiber diameter and number of motoneurons were significantly decreased in both the PRP and GRF groups, as compared with the control.Conclusion PRP within a vein conduit may be an effective alternative or adjuvant to GRF, the current preferred treatment for nerve injury with a nerve gap, and further investigations are required to fully define the role of PRP in nerve regeneration.
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    Peripheral nerve regeneration with conduits: use of vein tubes
    (Shenyang Editorial Dept Neural Regeneration Res, 2015-04-01) Sabongi, Rodrigo Guerra [UNIFESP]; Fernandes, Marcela [UNIFESP]; Santos, João Baptista Gomes dos [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Treatment of peripheral nerve injuries remains a challenge to modern medicine due to the complexity of the neurobiological nerve regenerating process. There is a greater challenge when the transected nerve ends are not amenable to primary end-to-end tensionless neurorraphy. When facing a segmental nerve defect, great effort has been made. to develop an alternative to the autologous nerve graft in order to circumvent morbidity at donor site, such as neuroma formation, scarring and permanent loss of function. Tubolization techniques have been developed to bridge nerve gaps and have been extensively studied in numerous:experimental and clinical trials. the use of a conduit intends to act as a vehicle for moderation and modulation of the cellular and molecular ambience for nerve regeneration. Among several conduits, vein tubes were validated for clinical application with improving outcomes over the Years. This article aims to address the investigation and treatment of segmental nerve injury and draw the current panorama on the use of vein tubes as an autogenous nerve conduit.