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- ItemAcesso aberto (Open Access)Gliomas múltiplos: casos ilustrativos de quatro formas de apresentação(Academia Brasileira de Neurologia - ABNEURO, 2000-03-01) Franco, Clélia Maria Ribeiro [UNIFESP]; Malheiros, Suzana Maria Fleury [UNIFESP]; Nogueira, Roberto Gomes [UNIFESP]; Batista, Marcus Azzar Sabry [UNIFESP]; Santos, Adrialdo José [UNIFESP]; Abdala, Nitamar [UNIFESP]; Stávale, João Norberto [UNIFESP]; Ferraz, Fernando Antônio Patriani [UNIFESP]; Gabbai, Alberto Alain [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Multiple gliomas are uncommon and may be classified according to: a) the time of presentation in early (at diagnosis) or late (during treatment); b) the characteristics of computed tomography or magnetic resonance imaging (CT/MRI) in multifocal (with evidence of spread) and multicentric (without evidence of spread). From 212 patients with histopathologic diagnosis of glioma evaluated from March/90 to September/99, 15 (7%) had multiple lesions. We describe 4 patients: early multicentric, late multicentric, early multifocal and late multifocal, with emphasis on characteristics of CT/MRI and possible differential diagnosis. The differential diagnosis of multiple lesions in the central nervous system includes mainly infectious/inflammatory diseases and metastasis, however multiple gliomas should always be considered, even in patients with known systemic cancer, as described by others. Considering that CT/MRI features are not definite, the diagnosis should always be confirmed by histopathologic examination.