Navegando por Palavras-chave "molecular forms, binding proteins"

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    Growth hormone axis in Cushing's syndrome
    (Karger, 1996-01-01) Wajchenberg, B. L.; Liberman, B.; Neto, D. G.; Morozimato, M. Y.; Semer, M.; Bracco, L. O.; Salgado, L. R.; Knoepfelmacher, M.; Borges, MHS; Pinto, ACAR; Kater, C. E.; Lengyel, AMJ; Universidade Federal de São Paulo (UNIFESP)
    All levels of the growth hormone (GH), GH binding protein (GHBP), insulin-like growth factor (IGF) and IGF binding protein (IGFBP) axis are influenced by chronic hypercortisolism. Thus, there is a blunted response to GHRH alone or together with other stimuli associated with a marked suppression of endogenous GH secretion but accompanied by normal GHBP, normal to low IGF-1 and GHBPs 1 and 3 with the correspondent 41.5 and 38.5-kD molecular forms of the latter presenting values similar to normal. These findings may suggest enhanced GH sensitivity with normal or increased IGF-1 bioavailability to the correspondent tissue receptors. In conclusion, the glucocorticoid (GC)-induced target tissue resistance can neither be attributed to the suppression of the GH axis nor to changes in circulating GHBPs 1 and 3. However, it may be related either to the described 12- to-20-kD inhibitor(s) which antagonizes postbinding IGF-1 bioactivity (gene expression) and/or by the downmodulation of activator protein-1 (Fos/Jun) activity by the GC-GC receptor complex.