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    Avaliação da função coclear e resposta tecidual da mucosa da cavidade timpânica de cobaia, quando receptora de implante biodegradável
    (Universidade Federal de São Paulo (UNIFESP), 2014-10-29) Garcia, Leandro de Borborema [UNIFESP]; Testa, Jose Ricardo Gurgel Testa [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Introduction:Treatment of cochlear disorders represents a promisingfuture in otology. Local drug delivery has distinct advantages for the treatmentof the inner ear disease. The developmentof prolonged drug delivery system, by biopolymers, may mean significant progress,once they are able to keep drug concentrations on the desired site within therapeutical levels for a long period of time. Objective: To evaluate the cochlear function and tissue response of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant.Methods: A total of 20 male guinea pigs were divided into 2 groups. After paracentesis in both ears, a biodegradable polymer of poly lactic-co-glycolic acid was implanted in only one middle ear. Histological analysis using neutrophil exudate and vascular neoformation (acute inflammation) and fibroblast proliferation and mononuclear inflammatory cells (chronic inflammation) as parameters was performed after 10 and 30 days of survival (groups 1 and 2, respectively). The Brain Stem Auditory Evoked Potentials was made in all ears justbefore the implantation of the biopolymer and the euthanasia. Results:Four ears in group 1 and 7 in group 2 had an increase of neutrophil exudate. Vascular neoformation occurred in ears with or without the implant, in both groups. Fibroblast proliferation and mononuclear inflammatory cells (lymphocytes and macrophages) increased in ears with implant in group 2. None of the groups showed sensorineural hearing loss. Conclusion:The cochlear function and tissue response by histological analysis of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant, showed no statistically significant difference between ears with or without the implant.
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    Epidemiology of middle ear and mastoid cholesteatomas. Study of 1146 cases
    (Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, 2011-05-01) Aquino, Jose Evandro Andrade Prudente de; Cruz Filho, Nelson Alvares; Aquino, Julia Negro Prudente de [UNIFESP]; Beneficencia Portuguesa Hosp; Cema; Universidade Federal de São Paulo (UNIFESP)
    Middle ear cholesteatoma is an important and relatively common disorder which may have serious consequences.Aim: The purpose was to conduct a retrospective study of the statistics of 1,146 middle ear surgical procedures for middle ear cholesteatoma in adults and children of low income living in distant areas from our city.Methods: From 1962 to 1988 there were 1,146 surgeries for unilateral or bilateral cholesteatomas in children and adults, which were reviewed for the following criteria: total number of surgeries, sex, onset of the first symptoms, duration of the disease, the site of perforation, the cholesteatoma site, changes in the ossicular chain, the contralateral ear, bilateral cholesteatomas, the site of residual cholesteatoma, and complications.Results: Results are shown graphically on a pie chart.Conclusion: The etiology of cholesteatomas remains unknown. Epidemiological and statistical data, surgical reports, and conclusions of experimental studies are welcome, as they may provide support for clarifying the pathogenesis of cholesteatoma. Our results were compared with internationally published papers. We found no published papers on the epidemiology of cholesteatoma in the Brazilian literature.