Navegando por Palavras-chave "medium-chain triglycerides"

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    Dietary Medium-Chain Triacylglycerols versus Long-Chain Triacylglycerols for Body Composition in Adults: Systematic Review and Meta-analysis of Randomized Controlled Trials
    (Routledge Journals, Taylor & Francis Ltd, 2015-03-04) Bueno, Nassib B. [UNIFESP]; Melo, Ingrid V. de; Florencio, Telma T.; Sawaya, Ana Lydia [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Univ Fed Alagoas
    Objective: To assess the effect of replacing dietary long-chain triacylglycerols (LCTs) with medium-chain triacylglycerols (MCTs) on body composition in adults.Methods: We conducted a meta-analysis of randomized controlled trials (RCTs), to determine whether individuals assigned to replace at least 5g of dietary LCTs with MCTs for a minimum of 4 weeks show positive modifications on body composition. We systematically searched, through July 2013, the CENTRAL, EMBASE, LILACS, and MEDLINE databases for RCTs that investigated the effects of MCT intake on body composition in adults. Two authors independently extracted data and assessed risk of bias. Weighted mean differences (WMDs) were calculated for net changes in the outcomes. We assessed heterogeneity by the Cochran Q test and I-2 statistic and publication bias with the Egger's test. Prespecified sensitivity analyses were performed.Results: in total, 11 trials were included, from which 5 presented low risk of bias. in the overall analysis, including all studies, individuals who replaced dietary LCT with MCT showed significantly reduced body weight (WMD, -0.69kg; 95% confidence interval [CI], -1.1 to -0.28; p = 0.001); body fat (-0.89kg; 95% CI, -1.27 to -0.51; p < 0.001), and WC (-1.78cm; 95% CI, -2.4 to -1.1; p < 0.001). the overall quality of the evidence was low to moderate. Trials with a crossover design were responsible for the heterogeneity.Conclusion: Despite statistically significant results, the recommendation to replace dietary LCTs with MCTs must be cautiously taken, because the available evidence is not of the highest quality.
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    Partial Replacement of omega-6 Fatty Acids With Medium-Chain Triglycerides, but Not Olive Oil, Improves Colon Cytokine Response and Damage in Experimental Colitis
    (Sage Publications Inc, 2012-07-01) Bertevello, Pedro L.; De Nardi, Leticia; Torrinhas, Raquel S.; Logullo, Angela F. [UNIFESP]; Waitzberg, Dan L.; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    Background: Soybean oil is rich in omega-6 fatty acids, which are associated with higher incidence and more severe cases of inflammatory bowel diseases. the authors evaluated whether partial replacement of soybean oil by medium-chain triglycerides (MCTs) or olive oil influenced the incidence and severity of experimental ulcerative colitis by using different parenteral lipid emulsions (LEs). Methods: Wistar rats (n = 40) were randomized to receive parenteral infusion of the following LE: 100% soybean oil (SO), 50% MCT mixed with 50% soybean oil (MCT/SO), 80% olive oil mixed with 20% soybean oil (OO/SO), or saline (CC). After 72 hours of infusion, acetic acid experimental colitis was induced. After 24 hours, colon histology and cytokine expression were analyzed. Results: SO was not significantly associated with overall tissue damage. MCT/SO was not associated with necrosis (P < .005), whereas OO/SO had higher frequencies of ulcer and necrosis (P < .005). SO was associated with increased expression of interferon-gamma (P = .005) and OO/SO with increased interleukin (IL)-6 and decreased tumor necrosis factor-alpha expression (P < .05). MCT/SO appeared to decrease IL-1 (P < .05) and increase IL-4 (P < .001) expression. Conclusions: Parenteral SO with high concentration of omega-6 fatty acids was not associated with greater tissue damage in experimental colitis. SO partial replacement with MCT/SO decreased the frequency of histological necrosis and favorably modulated cytokine expression in the colon; however, replacement with OO/SO had unfavorable effects. (JPEN J Parenter Enteral Nutr. 2012; 36: 442-448)