Navegando por Palavras-chave "materiais biocompatíveis"

Agora exibindo 1 - 2 de 2
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Estudo da integração da tela de polipropileno recoberta com materiais nanoestruturados em ratos
    (Universidade Federal de São Paulo (UNIFESP), 2014-05-28) Tussi Júnior, Roberto [UNIFESP]; Koh, Ivan Hong Jun Koh [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Purpose: Evaluate the biocompatibility of polypropylene mesh coated with nanostructured materials and analysis of abdominal content adhesions with polypropylene mesh. Methods: After deposition of silver, carbon and carbon plus silver nanoparticles, using the Nonthermal plasma technique at Plasma and Processes Laboratory of ITA. The meshes were implanted at acute defects of the anterior abdominal wall of female rats Wistar- EPM. The histology was used to analysis of mesh tissue interaction using HE and Picrosirius Red. The study of adhesions was done through sheer numbers of adhesions to the prosthesis, Zühlke criteria for adhesion strength and Diamond criteria for percentage of area covered by adhesions. Results: The polypropylene mesh coated with carbon and silver exclusively demonstrated an excellent biocompatibility with the absence of acute or chronic inflammatory response and with reduced type I collagen and increase type III collagen. However meshes treated with carbon and silver in the sequence presented with harmful perpetuation of acute inflammatory activity. In this group the fibroblasts collagen production was absent. Evidencing a higher degree of antigenicity than control group. The analysis of the number of adhesions was not statistically significant between groups, as well as the strength of the same Zühlke criteria. Already the percentage of area attached to the prosthetic tissue showed statistical significance in the groups covered with silver carbon and unique compared to the polypropylene group. Conclusion: The deposition of nanocomposites of silver and carbon on the polypropylene mesh showed a reduction of antigenicity with improved tissue incorporation. The percentage of mesh surgical adhesions were also benefited this group. Nanotechnological meshes treatment did not prevent the formation of adhesions. Different Nonthermal methods deposition and combinations of nanoparticles may influence with the biological response.
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    Ricinus communis biocompatibility histological study in the nose of Cebus apella monkeys
    (Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial, 2009-06-01) Dias, Paulo Cesar de Jesus [UNIFESP]; Granato, Lidio [UNIFESP]; Ramalho, Lizeti de Toledo de Oliveira; Oliveira, José Américo de; Pretel, Hermes; Universidade Federal de São Paulo (UNIFESP); Universidade Federal do Rio Grande do Sul Hospital de Clinicas de Porto Alegre; Santa Casa de São Paulo Faculdade de Ciências Médicas; Universidade Estadual Paulista (UNESP)
    Bone tissue lesions can be caused by congenital and acquired factors, and result in nasal deformities with cosmetic and functional repercussion. Surgical treatment in these cases frequently requires complex reconstructions and the use of biomaterials. The polyurethane derived from castor beans (Ricinus communis) has a favorable formulation in terms of ease of processing, flexibility, no emission of toxic vapors and low cost. Nonetheless, despite favorable results, studies about the use of castor beam polymer (Ricinus communis) assessing tissue reaction on the nasal dorsum are still missing in the literature. AIM: the goal of the present investigation is to histologically assess the Ricinus communis polymer implant biocompatibility with the nasal dorsum. STUDY DESING: experimental. MATERIALS AND METHODS: we used four Cebus appela monkeys, in which we created a nasal dorsal defect in all the animals and there we placed the aforementioned implant. The animals were sacrificed 270 days after surgery and the samples were submitted to histological study. RESULTS: in the histology analysis we did not observe the presence of foreign body granulomas or phagocytic cells. We also observed a progressive bone formation and maturation. CONCLUSION: macroscopic and microscopic results showed that the castor oil polymer implant was biocompatible.