Navegando por Palavras-chave "loop gain"

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    The Effect of Donepezil on Arousal Threshold and Apnea-Hypopnea Index A Randomized, Double-Blind, Cross-Over Study
    (Amer Thoracic Soc, 2016) Li, Yanru; Owens, Robert L.; Sands, Scott; Orr, Jeremy; Moraes, Walter [UNIFESP]; DeYoung, Pamela; Smales, Erik; Jen, Rachel; Malhotra, Atul
    Rationale: Obstructive sleep apnea (OSA) has multiple pathophysiological causes. A low respiratory arousal threshold (ArTh) and a high loop gain (unstable ventilatory control) can contribute to recurrent respiratory events in patients with OSA. Prior studies have shown that donepezil, an acetylcholinesterase inhibitor, might improve OSA, but the mechanism is unknown. Objectives: To determine whether a single dose of donepezil lowers the apnea-hypopnea index by modulating the ArTh or loop gain. Methods: In this randomized, double-blind, crossover trial, 41 subjects with OSA underwent two polysomnograms with ArTh and loop gain evaluated, during which 10 mg of donepezil or placebo was administered. Measurements and Main Results: Compared with placebo, sleep efficiency (77.2 vs. 71.9%