Navegando por Palavras-chave "lidocaine"
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- ItemAcesso aberto (Open Access)Avaliação da lidocaína tópica como pré-medicação para a endoscopia digestiva alta em crianças(Sociedade de Pediatria de São Paulo, 2009-12-01) Machado, Rodrigo Strehl [UNIFESP]; Viriato, Airton; Miranda, Áurea Cristina Portorreal [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); HICF Divisão de Apoio Diagnóstico e TerapêuticoOBJECTIVE: This study aims to evaluate the efficacy of topical lidocaine as an adjuvant drug to sedatives in children and adolescents undergoing digestive endoscopies. METHODS: 80 patients (49 females and 31 males, 12±3 years old) were randomly allocated into placebo (n=40) or lidocaine group (n=40). One patient was excluded from each group after allocation. Two puffs of either 10% lidocaine or placebo (tannic acid 0.5%) were sprayed into the oropharynx before the infusion of propofol. Patients were monitored during the procedure and answered a questionnaire after the procedure to evaluate sore throat and the medicine used as pre-medication. The primary outcome measure was propofol dose. Time spent in the procedure room, in the procedure and the incidence of complications were secondary outcome measures. RESULTS: Demographic data (age, sex and endoscopy indication) were evenly distributed in each group. The dose of propofol was not different between patients and controls (placebo group 3.1±1.1 and lidocaine group 2.9±1.3mg/kg; p=0.69), even considering the total dose (p=0.33). The time spent in the procedure room was longer for the placebo group than for the lidocaine group (23±7 versus 20±5 minutes; 95%CI of the difference: 0.47-5.89 minutes, p=0.02). There was no difference between groups regarding procedure duration, complications incidence and tolerability. CONCLUSIONS: Topic anesthetic medication reduces the time spent in the procedure room without increasing the incidence of side effects (NCT00521703).
- ItemSomente MetadadadosEffect of intravenous lidocaine combined with amitriptyline on pain intensity, clinical manifestations and the concentrations of IL-1, IL-6 and IL-8 in patients with fibromyalgia: A randomized double-blind study(Wiley, 2016) Giraldes, Ana Laura Albertoni [UNIFESP]; Salomão, Reinaldo [UNIFESP]; Leal, Plinio da Cunha [UNIFESP]; Brunialti, Milena Karina Coló [UNIFESP]; Sakata, Rioko Kimiko [UNIFESP]Aim: Regarding the use of intravenous lidocaine in fibromyalgia, there are no well-controlled studies. This study aimed to evaluate the effect of intravenous lidocaine on pain intensity, clinical manifestations and plasma levels of interleukin (IL)-1, IL-6, and IL-8 in fibromyalgia patients. Methods: In a randomized double-blind study, group 1 patients received 240 mg of lidocaine in 125 mL of saline solution, while group 2 patients received 125 mL of saline, both once a week for 4 weeks (T1, T2, T3 and T4). All patients received amitriptyline. The following were assessed: pain intensity before treatment (T0) and at 1, 2, 3, 4 and 8 weeks after treatment
- ItemSomente MetadadadosPilot Study Comparing Topical Anesthetic Agents in Pterygium Surgery: Subconjunctival Injection Versus 2% Lidocaine Gel Versus 5% Lidocaine Gel(Lippincott Williams & Wilkins, 2018) Pereira, Felipe [UNIFESP]; Shiroma, Helio Francisco [UNIFESP]; Urias, Muller Goncalves [UNIFESP]; Yamada, Veronica Haysa [UNIFESP]; de Souza Lima, Acacio Alves [UNIFESP]; Hofling-Lima, Ana Luisa [UNIFESP]; Farah, Michel Eid [UNIFESP]; Rodrigues, Eduardo Buchele [UNIFESP]Purpose: To compare the efficacy of different concentrations of topical lidocaine gel with standard subconjunctival anesthesia. Methods: This was a prospective randomized controlled pilot study with 3 different groups. Group SC received subconjunctival lidocaine and proparacaine drops as needed during surgery. Group L2 received 2% lidocaine gel and group L5 received 5% lidocaine gel. Both lidocaine gel groups could receive another gel dose as needed during the procedure. The primary outcome was pain, which was experienced during and after surgery. The assessment was done using a 10-point linear analog scale at predetermined stages of surgery (1-first incision, 2-pterygium body excision, 3-conjunctival suturing, 4-immediate postoperative period after patching, and 5-assessment by a trained nurse in the absence of a surgeon after operation). Results: We enrolled 45 consecutive patients who underwent primary pterygium surgery. Statistical significance between groups was found in mean pain at administration (2.2 vs. 0.4 vs. 0.0 in SC, L2, and L5 groups, respectively, with P < 0.05). The number of reapplications of anesthetic drops did not differ between the groups. We found a correlation between reapplication of the anesthetic and pain at administration and duration of the procedure. Conclusions: We demonstrated that the use of lidocaine gel at concentrations of 2% and 5% in pterygium surgery was as effective as subconjunctival injection of lidocaine in reducing intraoperative and postoperative pain, producing significantly less pain during initial administration of the anesthetic.