Navegando por Palavras-chave "intersex"
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- ItemSomente MetadadadosEvaluation of the tubular and interstitial functions of the testis in 46,XY patients with ambiguous genitalia(Freund Publishing House Ltd, 2000-06-01) Stuchi-Perez, E. Gabas; Lukas-Croisier, C.; De Castro, M.; Baptista, MT Matias; Scolfaro, M. Ribeiro; Marques-De-Faria, A. P.; Hackel, C.; Maciel-Guerra, A. T.; Guerra, G.; Universidade Estadual de Campinas (UNICAMP); Ecole Normale Super; Universidade Federal de São Paulo (UNIFESP)Investigation of the origin of sexual ambiguity is complex. Although testicular function has traditionally been assessed only by examining the steroidogenic capacity of Leydig cells and spermatogenesis, it has recently been shown that the measurement of serum anti-Mullerian hormone (AMH) as a marker of Sertoli cell function may also help clinicians. The aim of this study was to evaluate both Leydig and Sertoli cell functions in 46,XY patients with intersex states in order to establish biochemical patterns that would help to reach an etiologic diagnosis. We measured serum androgens, AMH and gonadotropins in 24 patients with sexual ambiguity and XY karyotype: 8 with gonadal dysgenesis (GD), 3 with 3 beta-hydroxy-steroid dehydrogenase deficiency (3 beta HSD), 5 with androgen insensitivity syndrome (AIS), 4 with 5 alpha-reductase 2 (SRD5A2) deficiency, and 4 were of unknown origin or idiopathic, Our results showed that while testosterone was low and gonadotropins elevated in patients with either GD or 3 beta HSD, AMH was low in the former and high in the latter. Serum AMH and gonadotropins were normal or high in patients with 3 beta HSD or AIS, but these could be distinguished by testosterone levels. Serum testosterone and gonadotropins were normal or high in AIS and SRD5A2 deficiency patients; however, while AMH was elevated in AIS, it was not the case in SRD5A2 deficiency patients, indicating that testosterone is sufficient to inhibit AMH within the testis. In idiopathic cases gonadotropins and testosterone were normal, and AMH was normal or low. We conclude that the combined measurement of androgens, AMH and gonadotropins helps to establish the diagnosis in intersex patients.
- ItemAcesso aberto (Open Access)Intersexo e (in)visibilidade: cidadania e saúde na busca do registro geral de identificação (RG)(Universidade Federal de São Paulo (UNIFESP), 2014-10-10) Lima, Shirley Acioly Monteiro de [UNIFESP]; Pereira, Pedro Paulo Gomes [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)The objective of this thesis is to ethnograph the itinerary of intersex people in search of a new Identification Card (ID). In order to regularize the birth certificate and I.D, intersex people need to seek medical endorsement, go through surgical interventions to change their body and/or obtain medical reports. This ethnography follows two of these trajectories and focused on the encounter and the relation established by adult intersex people and the groups involved on their care: social, medical and law. This thesis is about their path, the process of affirmation of an identity by which they wanted to be known and socially called. This process demonstrates that the restriction of knowledge about intersexuality within the biomedical sphere, has kept intersex people invisible to the State or, at most, tied to pathologized diagnoses, which constrain their way out of the health system.
- ItemSomente MetadadadosTrue hermaphroditism - the importance of ultrasonic assessment(Wiley-Blackwell, 2005-07-01) Pires, Claudio Rodrigues [UNIFESP]; Poli, AHM; Zanforlin Filho, Sebastiao Marques [UNIFESP]; Mattar, Rosiane [UNIFESP]; Moron, Antonio Fernandes [UNIFESP]; Diniz, Angélica Lemos Debs [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Ultrasound Training Ctr São PauloIntersex states are associated with rare syndromes within a wide clinical spectrum, true hermaphroditism being the rarest of them all. It is a condition that is characterized by ovotestis, i.e. the presence of ovarian and testicular tissues in the same individual, either in separate gonads or in the same gonad. Diagnostic investigation of hermaphroditism involves ultrasound examination of the gonads, karyotype analysis and histological studies. We report the case of a 21-year-old individual with true hermaphroditism, in whom ovotestis was diagnosed on ultrasonography and which was later confirmed by anatomopathological study of the gonads. the role of ultrasound in the initial diagnostic investigation of intersex states, especially true hermaphroditism, is discussed. Copyright 2005 (c) ISUOG.