Navegando por Palavras-chave "interleukin-18"

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    Inflammasome gene profile is modulated in septic patients, with a greater magnitude in non-survivors
    (Wiley, 2017) Esquerdo, K. F. [UNIFESP]; Sharma, N. K. [UNIFESP]; Brunialti, M. K. C. [UNIFESP]; Baggio-Zappia, G. L. [UNIFESP]; Assuncao, M.; Azevedo, L. C. P.; Bafi, A. T. [UNIFESP]; Salomao, R. [UNIFESP]
    Inflammasome signalling induces the processing and secretion of interleukin (IL)-1 and IL-18 which, coupled with pyroptosis, activate further the inflammatory response. In the present study we evaluated the expression of genes involved in inflammasome signalling pathways in septic patients, their interaction networks and the predicted functions modulated in survivors and non-survivors. Twenty-seven patients with sepsis secondary to community-acquired pneumonia admitted to intensive care units from three general hospitals in SAo Paulo were included into the study. We performed a polymerase chain reaction (PCR) array encompassing 35 genes related to the nucleotide-binding oligomerization domain and leucine-rich repeat-containing (NLR)-inflammasome in peripheral blood mononuclear cells obtained at admission and after 7 days of follow-up. Eleven healthy volunteers were used as the reference group. Increased NLRC4 and NLRP3 and decreased nucleotide-binding oligomerization domain (NOD1), and NLRP1 expression was observed in septic patients compared to healthy individuals