Navegando por Palavras-chave "interleukin-1 beta"

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    CD36 Shunts Eicosanoid Metabolism to Repress CD14 Licensed Interleukin-1 beta Release and Inflammation
    (Frontiers Media Sa, 2018) Zoccal, Karina F.; Gardinassi, Luiz G.; Sorgi, Carlos A.; Meirelles, Alyne F. G.; Bordon, Karla C. F.; Glezer, Isaias [UNIFESP]; Cupo, Palmira; Matsuno, Alessandra K.; Bollela, Valdes R.; Arantes, Eliane C.; Guimaraes, Francisco S.; Faccioli, Lucia Helena
    Interleukin (IL)-1 beta is a potential target for treatment of several inflammatory diseases, including envenomation by the scorpion Tityus serrulatus. In this context, bioactive lipids such as prostaglandin (PG)E-2 and leukotriene (LT)B-4 modulate the production of IL-1 beta by innate immune cells. Pattern recognition receptors (PRRs) that perceive T. serrulatus venom (TsV), and orchestrate LTB4, PGE(2), and cyclic adenosine monophosphate (cAMP) production to regulate IL-1 beta release are unknown. Furthermore, molecular mechanisms driving human cell responses to TsV remain uncharacterized. Here, we identified that both CD14 and CD36 control the synthesis of bioactive lipids, inflammatory cytokines, and mortality mediated by TsV. CD14 induces PGE(2)/cAMP/IL-1 beta release and inflammation. By contrast, CD36 shunts eicosanoid metabolism toward production of LTB4, which represses the PGE(2)/cAMP/IL-1 beta axis and mortality. Of importance, the molecular mechanisms observed in mice strongly correlate with those of human cell responses to TsV. Overall, this study provides major insights into molecular mechanisms connecting CD14 and CD36 with differential eicosanoid metabolism and inflammation mediated by IL-1 beta.
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    Cytokine and hormonal profile in serum samples of patients undergoing controlled ovarian stimulation: interleukin-1 beta predicts ongoing pregnancy
    (Oxford Univ Press, 2010-08-01) Bonetti, Tatiana Carvalho de Souza [UNIFESP]; Salomao, Reinaldo [UNIFESP]; Brunialti, Milena Karina Coló [UNIFESP]; Braga, D. P. A. F.; Borges Júnior, Edson [UNIFESP]; Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Fertil Assisted Fertilizat Ctr
    Changes in the endometrium are not regulated exclusively by ovarian hormones; the immune system has also been implicated in normal endometrial function, similar to processes taking place during inflammatory and reparative path. Many cytokines are crucially important for reproductive processes, and the role of cytokines in the female reproductive system function has been broadly investigated during controlled ovarian stimulation (COS) for IVF attempts. the aim of this study was to evaluate the levels of serum cytokines and hormones, and the clinical outcomes of women who underwent COS and ICSI procedures.The study prospectively included 96 patients (aged 22-43 years, unexplained or male infertility, n = 61; female infertility factors, n = 35) who underwent ICSI cycles. Serum levels of interleukin (IL-8, IL-6, IL-1 beta, IL-10, IL-12), tumour necrosis factor and leukaemia-inhibitory factor (LIF) and the hormones FSH, estradiol, progesterone, anti-Mullerian hormone and Inhibin-B were measured on the day of oocyte retrieval.The ongoing pregnancy rate was 25.3%. the presence of serum IL-1 beta positively affected the implantation rate (P = 0.004) and increased the chance of becoming pregnant by 15 fold. Furthermore, the percentage of patients with detectable serum IL-1 beta levels who conceived (62.5%) was higher than those who failed to conceive (37.5%; P = 0.019). the LIF was undetectable in all serum samples, and no other factors influenced the clinical outcomes of patients undergoing ICSI cycles.Our findings revealed that detectable serum levels of IL-1 beta on the day of oocyte retrieval in patients undergoing COS and ICSI are predictive of successful implantation and ongoing pregnancy.