Navegando por Palavras-chave "il1β"

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    A Interleucina 1-beta mostra uma ação protetora na fase aguda do modelo de epilepsia induzido pela pilocarpina
    (Liga Brasileira de Epilepsia (LBE), 2010-09-01) Pascoal, Vinícius d b; Marchesini, Rafael Breglio; Matos, Anabela hb; Conte, Fábio Frangiotti; Pereira, Tiago Campos; Gilioli, Rovilson; Malheiros, Jackeline Moraes [UNIFESP]; Polli, Roberson Saraiva [UNIFESP]; Buzzá, Hilde H; Tannús, Alberto; Covolan, Luciene [UNIFESP]; Cavalheiro, Esper Abrão [UNIFESP]; Velloso, Lício Augusto; Cendes, Fernando; Lopes-Cendes, Íscia; Universidade Estadual de Campinas (UNICAMP); Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    INTRODUCTION: There is contradictory information regarding the of effects il1β and il1rn in epilepsy. We aimed to evaluate the effect of silencing both genes in the acute phase of the pilocarpine-induced epilepsy model. METHODS: We used RNA interference in order to achieve gene silencing. RESULTS: We obtained significant gene silencing in the central nervous system. In addition, we observed phenotypic effects including differences in mortality rates of animals 5 days after pilocarpine injections. CONCLUSION: Our results indicate that il1β seems to have a protective effect in the acute phase of the pilocarpine-induced epilepsy model.