Navegando por Palavras-chave "habitual abortion"
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- ItemAcesso aberto (Open Access)Depression in Women with Recurrent Miscarriages - an Exploratory Study(Federacao Brasileira Soc Ginecologia & Obstetricia-Febrasgo, 2016) Carvalho, Ariel Cesar de [UNIFESP]; Silva, Michele Eugenio da [UNIFESP]; Matos, Barbara Magueta [UNIFESP]; de Campos Bottino, Cassio Machado; Abrahão, Anelise Riedel [UNIFESP]; Cohrs, Frederico Molina [UNIFESP]; Bottino, Sara Mota Borges [UNIFESP]Objective To assess depression, domestic violence and the use of substances in women with recurrent miscarriages. Methods The Abuse Assessment Screen (AAS), the Edinburgh Postnatal Depression Scale (EPDS) and the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) were used to assess violence, depression and the use of substances among women with recurrent miscarriages. The population corresponded to patients receiving prenatal care from June to August 2014. Multiple logistic regression was used to assess the multivariable relationship between depression and sociodemographic, psychosocial and medical characteristics (p < 0,10). Results The prevalence of depression was of 41.3% (95% confidence interval [CI] = 28.3-55.7%). One third of the pregnant women (32.6%) reported emotional or physical violence, and 13% were classified as abusing or addicted to tobacco according to ASSIST. History of psychiatric diseases was associated with depression (p = 0.005). Violence during life demonstrated a modest association (p = 0.073) with depression, as well as the number of miscarriages (p = 0.071). Conclusion Depression is a frequent disease among pregnant women with recurrent miscarriages. The results of this investigation suggest that a systematic assessment of depression and its associated conditions, such as domestic violence and the use of substances, should be part of the prenatal follow-up visits for women with recurrent miscarriages.
- ItemSomente MetadadadosGenetic Polymorphisms and Recurrent Spontaneous Abortions: An Overview of Current Knowledge(Wiley-Blackwell, 2012-04-01) Daher, Silvia [UNIFESP]; Mattar, Rosiane [UNIFESP]; Gueuvoghlanian-Silva, Barbara Y. [UNIFESP]; Torloni, Maria R. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)The relevance of gene polymorphisms in the development of unexplained recurrent spontaneous abortion is still unclear. Cytokines, angiogenic mediators, and hormones are involved in all stages of reproduction and pregnancy outcome. Impaired production and/or unbalanced ratios of these mediators have been implicated in the pathogenesis of unexplained recurrent spontaneous abortion. Functional polymorphism influence gene activity and therefore can interfere with the expression of mediators. Several studies have been carried out to evaluate the relationship between cytokines, angiogenic mediators, and hormones gene polymorphisms and unexplained recurrent spontaneous abortion. the results of these studies are mostly contradictory, and few significant associations have been identified. Up to present time, the evidence is insufficient to support the evaluation of cytokines, angiogenic mediators, and hormones gene polymorphism in routine workup in all cases of recurrent pregnancy loss, and these tests are not included in any of the major obstetric guidelines.