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- ItemSomente MetadadadosThe Central Nervous System as Target for Antihypertensive Actions of a Proline-Rich Peptide from Bothrops jararaca Venom(Wiley-Blackwell, 2010-03-01) Lameu, Claudiana; Hayashi, Mirian Akemi Furuie [UNIFESP]; Guerreiro, Juliano R.; Oliveira, Eduardo F.; Lebrun, Ivo; Pontieri, Vera; Morais, Katia L. P.; Camargo, Antonio C. M.; Ulrich, Henning; Universidade de São Paulo (USP); Inst Butantan; Universidade Federal de São Paulo (UNIFESP)Pyroglutamyl proline-rich oligopeptides, present in the venom of the pit viper Bothrops jararaca (Bj-PROs), are the first described naturally occurring inhibitors of the angiotensin I-converting enzyme (ACE). the inhibition of ACE by the decapeptide Bj-PRO-10c (