Navegando por Palavras-chave "finasteride"

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    The anxiolytic effect of pregnancy in rats is reversed by finasteride
    (Elsevier B.V., 2006-11-01) Faturi, Claudia de Brito; Teixeira-Silva, Flavia; Leite, Jose Roberto; Universidade Federal de Sergipe (UFS); Universidade Federal de São Paulo (UNIFESP)
    Several studies have shown the influence of the oestrous cycle on anxiety levels and the important role of progesterone in this effect. the metabolism of this steroid hormone yields neuroactive steroids among them allopregnatiolone (alloP) and allotetrahydrodeoxycorticosterone (alloTHDOC), which bind to GABA(A) receptors and have anxiolytic effects. Considering that during pregnancy there is an increase in levels of both progesterone and its metabolites, the main objectives of this work were: (1) to assess changes in anxiety levels during pregnancy and (2) to verify the role of alloP and alloTHDOC in this process using finasteride, an inhibitor of 5 alpha-reductase, the enzyme responsible for their synthesis.The results showed a significant reduction in anxiety levels on the 19th day of pregnancy, which was reversed by finasteride, suggesting a role for alloP and alloTHDOC in the anxiolytic process. (c) 2006 Elsevier Inc. All rights reserved.
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    The benefits of finasteride for hirsute women with polycystic ovary syndrome or idiopathic hirsutism
    (Parthenon Publishing Group, 2003-02-01) Lakryc, E. M.; Motta, ELA; Soares, J. M.; Haidar, Mauro Abi [UNIFESP]; Lima, G. R. de; Baracat, E. C.; Universidade Federal de São Paulo (UNIFESP)
    Finasteride has been used frequently), in the treatment of prostate hyperplasia but this drug inhibits 5alpha-reductase and for this reason could be useful for the treatment (of hirsutism. the aim of this study was to evaluate the clinical and hormonal effects of finasteride on hirsute women with idiopathic hirsutism or polycystic ovary syndrome. Twenty-four women were randomly divided into two groups: those given placebo and those given finasteride 5 mg/day. the treatment, period was 6 months. All patients were evaluated before the beginning of treatment (baseline) and after 3 and 6 months of treatment using clinical examination through, Ferriman-Gallwey score, blood pressure, cardiac frequency and body mass index. Also, we collected blood for hormonal determination of levels of prolactin, 17alpha-hydroxyprogesterone, follicle stimulating hormone, luteinizing hormone, total and free testosterone, dehydroepiandrosterone sulfate, androstenedione and dihydrotestosterone. Furthermore, all patients were asked about their concerns and satisfaction with the treatment. the results showed that the Ferriman-Gallwey score in the 6th months of finasteride treatment was significantly lower than at baseline and the 3rd month of this drug treatment. the dihydrotestosterone level in the finasteride group was also si significantly, reduced compared to that in the placebo group. the other hormones did not show any statistical difference during the study. All the patients treated with finasteride perceived a reduction in hirsutism after 6 months. in conclusion, our data suggest that finasteride may be effective for the treatment of the hirsute women with idiopathic hirsutism or polycystic ovary syndrome.