Navegando por Palavras-chave "fatores de transcrição"

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    Expressão de marcadores relacionados ao potencial de diferenciação celular da articulação temporomandibular (atm) em fetos humanos
    (Universidade Federal de São Paulo (UNIFESP), 2016-05-31) Pagni, Tacia Catharine [UNIFESP]; Silva, Marcelo Cavenaghi Pereira da Silva [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    This study evaluated the immunohistochemical expression of proteins: OCT-4, NANOG, SOX-2, SOX-5 and STAT-3, which together characterize pluripotent embryonic cells. Methods: Twenty ATMs human fetuses aged between 12 and 20 weeks were used. Samples were dissected, fixed, decalcified, embedded in paraffin, cut and stained with hematoxylin / eosin for localization and subsequent immunohistochemical reaction. Results: NANOG, SOX-5 and STAT-3 showed cytoplasmic and nuclear staining in almost all cell layers of the mandibular fossa (dense connective layer, fibrocartilage, and proliferative bone formation), articular disc and the mandibular condyle (fibrous layer, proliferative, chondrocytes, hypertrophic chondrocytes and bone formation. It was not observed immunostaining for OCT-4 and SOX-2 in temporomandibular joint of human fetuses. Conclusion: Cell populations in this stage of ATM development have no characteristics of pluripotent cells but cells in differentiation.