Navegando por Palavras-chave "esclerose amiotrófica lateral"

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    Epidemiological and clinical factors impact on the benefit of riluzole in the survival rates of patients with ALS
    (Assoc Arquivos Neuro- Psiquiatria, 2017) Favero, Francis Meire [UNIFESP]; Voos, Mariana Callil; de Castro, Isac; Caromano, Fatima Aparecida; Bulle Oliveira, Acary Souza [UNIFESP]
    Objective: To investigate the impact of epidemiological and clinical factors on the benefit of riluzole in patients with amyotrophic lateral sclerosis (ALS). Methods: The survival rate of 578 patients with ALS (1999-2011) was analyzed by descriptive statistics and Kaplan-Meier curves. Considering the median of the sample survival time (19 months), patients were divided in two groups: below (B19) and above the median (A19). Kaplan-Meier curves compared the survival rates of patients treated with riluzole and with patients who did not take the medication. Results: Riluzole increased the survival rates of patients with lower limb onset who were diagnosed after the first appointment in B19. Patients with bulbar onset and diagnosed on the first, or after the first appointment showed higher survival rates in A19. Males lived longer than females in both groups. Conclusion: Epidemiological and clinical factors influenced the benefit of riluzole in the survival rates of patients with ALS.
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    Vídeoendoscopia da deglutição na esclerose lateral amiotrófica
    (Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial, 2013-06-01) D'ottaviano, Fabiana Gonçalez; Linhares Filho, Tarcisio Aguiar; Andrade, Helen Maia Tavares de; Alves, Percilia Cardoso Lopes [UNIFESP]; Rocha, Maria Sheila Guimarães [UNIFESP]; Hospital Santa Marcelina Residência Médica em otorrinolaringologia; clínica Otorhinus; Hospital Santa Marcelina Ambulatório de Doenças Neuromusculares; Hospital Santa Marcelina Residência Médica em Neurologia; Universidade Federal de São Paulo (UNIFESP); Hospital do Câncer A. C. Camargo Motricidade Oral em Oncologia; Hospital Santa Marcelina; Hospital Santa Marcelina programa de residencia médica em neurologia
    Amyotrophic lateral sclerosis (ALS) is a progressive degenerative motor neuron disease that adversely affects the muscles responsible for swallowing. OBJECTIVE: To assess the oral preparatory, oral transit and pharyngeal phases of swallowing in ALS patients through endoscopic evaluation. METHOD: This cross-sectional historical cohort study included ALS patients submitted to endoscopic examination. Eleven patients (six males and five females; mean age of 61.7 years) were enrolled in the study from january to december of 2011. RESULTS: All patients had alterations in phases of the swallowing process, but only 72.7% complained of dysphagia. The oral preparatory phase was altered in 63.6% of the subjects; the oral transit and pharyngeal phases were altered in all studied individuals, regardless of food consistency. Laryngeal penetration or tracheal aspiration were seen in 90.9% of the patients during the pharyngeal phase while they were swallowing fluids. CONCLUSION: Even in the absence of complaints, dysphagia is a frequent comorbidity in ALS patients. The oral transit and pharyngeal phases were the most frequently affected. Laryngeal penetration or tracheal aspiration occurred more frequently during the pharyngeal phase while patients were swallowing fluids.