Navegando por Palavras-chave "demyelinating diseases"

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    Neuromyelitis Optica With Onset in Childhood and Adolescence
    (Elsevier B.V., 2014-01-01) Fragoso, Yara Dadalti; Ferreira, Maria L. B.; Oliveira, Enedina M. L. [UNIFESP]; Domingues, Renan B.; Ribeiro, Taysa A. G. J.; Brooks, Joseph B. B.; Claudino, Rinaldo; Netto, Jussara M. K.; Gomes, Sidney; Adoni, Tarso; Carneiro, Denise S. D.; Fonseca, Daiana R. P.; Fragomeni, Manuela O. [UNIFESP]; Oliveira, Francisco T. M.; Oliveira, Celso L. S.; Saldanha, Patricia C. O.; Souza, Jorge M. B.; Univ Metropolitana Santos; Hosp Restauracao; Universidade Federal de São Paulo (UNIFESP); Santa Casa Vitoria; Universidade Federal de Goiás (UFG); Universidade Federal de Santa Catarina (UFSC); Universidade Federal do Rio de Janeiro (UFRJ); Hosp Beneficencia Portuguesa; Hosp Paulistano; Hosp Sirio Libanes
    BACKGROUND: Neuromyelitis optica with onset before the age of 18 years is a relatively rare, yet potentially devastating condition. the objective of the present study was to contribute to the study of early-onset neuromyelitis optica with a case series. PATIENTS: Data were collected from medical records of Brazilian neurologists caring for patients with neuromyelitis optica occurring in childhood and adolescence. RESULTS: Twenty-nine patients with neuromyelitis optica occurring before the age of 18 years and fulfilling the diagnostic criteria were identified. the average age at disease onset was 13 years and the patients had had an average disease duration of 6 years. the expanded disability scale score at the latest consultation was, on average, 4.7, and one patient had died from the disease. the 29 patients had had an average 4.5 relapses during the disease, accounting for 0.75 relapses per year, irrespective of the medication used. All patients were using one or more of the following medications: azathioprine, prednisone, immunoglobulin, and glatiramer acetate. CONCLUSIONS: Neuromyelitis optica with onset in childhood and adolescence is a poorly understood condition that is often disabling and difficult to manage.
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    Patients with neuromyelitis optica have a more severe disease than patients with relapsingremitting multiple sclerosis, including higher risk of dying of a demyelinating disease
    (Academia Brasileira de Neurologia - ABNEURO, 2013-05-01) Bichuetti, Denis Bernardi [UNIFESP]; Oliveira, Enedina Maria Lobato de [UNIFESP]; Souza, Nilton Amorin de; Tintoré, Mar; Gabbai, Alberto Alain [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Hospital Universitari Vall d?Hebron Center d?Esclerosi Múltiple de Catalunya-CEMcat
    Although neuromyelitis optica (NMO) is known to be a more severe disease than relapsing-remitting multiple sclerosis (RRMS), few studies comparing both conditions in a single center have been done.Methods: Comparison of our previously published cohort of 41 NMO patients with 177 RRMS patients followed in the same center, from 1994 to 2007. Results: Mean age of onset was 32.6 for NMO and 30.2 for RRMS (p=0.2062) with mean disease duration of 7.4 years for NMO and 10.3 years for RRMS. Patients with NMO had a higher annualized relapse rate (1.0 versus 0.8, p=0.0013) and progression index (0.9 versus 0.6, p≪0.0001), with more patients reaching expanded disability status scale (EDSS) 6.0 (39 versus 17%, p=0.0036). The odds ratio for reaching EDSS 6.0 and being deceased due to NMO in comparison to RRMS were, respectively, 3.14 and 12.15. Conclusion: Patients with NMO have a more severe disease than patients with RRMS, including higher risk of dying of a demyelinating disease.