Navegando por Palavras-chave "complicações na gravidez"

Agora exibindo 1 - 3 de 3
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    Human fetal malformations associated with the use of an angiotensin II receptor antagonist: Case Report
    (Sociedade Brasileira de Nefrologia, 2014-09-01) Korkes, Henri Augusto; Oliveira, Leandro Gustavo de; Berlinck, Livia; Goes, Fernanda Sampaio; Borges, Antonio Fernando Allemand; Mastroianni Kirsztajn, Gianna [UNIFESP]; Sass, Nelson [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Maternidade Escola de Vila Nova Cachoeirinha; Hospital Servidor Publico Estadual de São Paulo; Universidade de São Paulo (USP)
    Introduction: The potential risks related to drug exposure during pregnancy represent a vast chapter in modern obstetrics and data regarding the safety of antihypertensive drugs during pregnancy are relatively scarce. Case report: A 37-year-old patient discovered her fifth pregnancy at our hospital after 26 weeks and 4 days of gestation. She reported a history of hypertension and was currently being treated with Losartan. Hospitalization was recommended for the patient and further evaluation of fetal vitality was performed. On the fourth day an ultrasound was performed, resulting in a severe oligohydramnios, fetal centralization and abnormal ductus venosus. After 36 hours, the newborn died. Pathologic evaluation: At autopsy, the skullcap had large fontanels and deficient ossification. The kidneys were slightly enlarged. A microscopic examination detected underdevelopment of the tubules and the presence of some dilated lumens. Immunohistochemical detection of epithelial membrane antigen was positive. Immunoreactivity of CD 15 was also assayed to characterize the proximal tubules, and lumen collapse was observed in some regions. Discussion: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor antagonists (ARAs) are among the most widely prescribed drugs for hypertension. They are often used by hypertensive women who are considering become pregnant. While their fetal toxicity in the second or third trimesters has been documented, their teratogenic effect during the first trimester has only recently been demonstrated. Conclusion: Constant awareness by physicians and patients should be encouraged, particularly in regard to the prescription of antihypertensive drugs in women of childbearing age who are or intend to become pregnant.
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    Litíase urinária e gestação
    (Sociedade Brasileira de Nefrologia, 2014-09-01) Korkes, Fernando; Rauen, Eduardo Costa; Heilberg, Ita Pfeferman [UNIFESP]; Faculdade de Medicina do ABC; Hospital Israelita Albert Einstein; Hospital São Luiz; Universidade Federal de São Paulo (UNIFESP)
    The diagnosis of urolithiasis during pregnancy is common, even though no additional measures are required in asymptomatic cases. Renal colic or complications of urinary lithiasis occur more frequently during the last months of pregnancy, and there are several particularities for the diagnosis and treatment of this subset of women. The present manuscript aim to review the current knowledge concerning this subject and present authors personal experience.
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    Preeclampsia
    (Federacao Brasileira Soc Ginecologia & Obstetricia-Febrasgo, 2017) Lopes Ramos, Jose Geraldo; Sass, Nelson [UNIFESP]; Martins Costa, Sergio Hofmeister
    The authors review hypertensive disease during pregnancy with an academic and practical view, and using the best evidence available. This disease, which is the most important clinical disease in Brazilian pregnant women, may have its incidence reduced with prevention through the use of calcium and aspirin in pregnant women at risk. Previously, it was a disease that presented with hypertension with proteinuria, but it has now been classified with new clinical parameters besides proteinuria. Morbidity and mortality should be reduced in a continental country such as Brazil using protocols for the early treatment of complications by calculating severe outcomes in preeclampsia. The early treatment of acute hypertension, use of magnesium sulfate and early hospitalization in cases of preeclampsia are concepts to pursue the reduction of our pregnant women's mortality.