Navegando por Palavras-chave "colesteatoma da orelha média"

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    Efeito do ácido trans-retinóico na inibição de colesteatoma em cobaias
    (ABORL-CCF Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial, 2008-02-01) Antunes, Marcos Luiz; Fukuda, Yotaka [UNIFESP]; Penido, Norma de Oliveira [UNIFESP]; Ferreira, Rimarcs Gomes [UNIFESP]; Faculdade de Medicina do ABC; Universidade Federal de São Paulo (UNIFESP)
    Middle ear cholesteatoma affected more than 5 million people until the 80`s. Many animal models were used, unsuccessfully, to study an alternative therapy to cholesteatoma. AIM: observe the effect of the trans-retinoic acid in the inhibition of middle ear cholesteatomas induced by propylene glycol. STUDY DESIGN: Clinical and Experimental. METHODS: 25 guinea pigs were submitted to the application of a 100% propylene glycol solution in their bulla bilaterally and a solution of trans-retinoic acid was applied locally in the external right ear, while in the left ear saline solution was applied (control ear). The guinea pigs were slaughtered and their temporal bones were prepared for macroscopic and histological analysis. RESULTS: The macroscopic findings had evidenced the presence of cholesteatoma in 25% of the right ears and 85% of the left ears (P=0.0003 *). The histological study had evidenced the presence of cholesteatoma in 30% of right ears and 75% of the left ears (P=0.0104*). CONCLUSION: The local use of the trans-retinoic acid is effective in inhibiting the induced formation of cholesteatomas in guinea pigs.
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    Impacto da endoscopia no tratameno do colesteatoma
    (Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial, 2013-08-01) Lima, Thiago de Oliveira [UNIFESP]; Araújo, Taís Figueiredo de; Soares, Letícia Clemente Alvim; Testa, Jose Ricardo Gurgel [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Hospital Santa Marcelina; Otorhinus Clínica Médica
    Recurrent cholesteatoma is relatively uncommon. Residual middle ear cholesteatomas account for most of the cases of recurrent disease. The limited role of microscopy in the visualization of tridimensional anatomic alterations of the temporal bone led to the use of endoscopic examination as an additional tool in the realm of ear surgery. Endoscopy has significantly aided in the management of chronic cholesteatomatous otitis media and in the prevention of recurrent disease. OBJECTIVE: To review the literature and assess the relevance of endoscopy in the surgical treatment of cholesteatomas and in the prevention of relapsing lesions. METHOD: Searches on databases MedLine and LILACS were carried out between March and June of 2011 to select studies in which endoscopy was used in the management of cholesteatomas. RESULTS: Three studies comparing surgery aided by endoscopy and surgery performed with the aid of a microscope met the inclusion criteria. CONCLUSION: Endoscopy has positively impacted the management of cholesteatomas and should be used in cholesteatoma surgery.