Navegando por Palavras-chave "cell signaling"

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    Candida albicans: The Ability to Invade Epithelial Cells and Survive under Oxidative Stress Is Unlinked to Hyphal Length
    (Frontiers Media Sa, 2017) Maza, Paloma K. [UNIFESP]; Bonfim-Melo, Alexis [UNIFESP]; Padovan, Ana C. B. [UNIFESP]; Mortara, Renato A. [UNIFESP]; Orikaza, Cristina M. [UNIFESP]; Damas Ramos, Lilian M.; Moura, Tauany R.; Soriani, Frederico M.; Almeida, Ricardo S.; Suzuki, Erika [UNIFESP]; Bahia, Diana [UNIFESP]
    In its hyphal form, Candida albicans invades epithelial and endothelial cells by two distinct mechanisms: active penetration and induced endocytosis. The latter is dependent on a reorganization of the host cytoskeleton (actin/cortactin recruitment), whilst active penetration does not rely on the host's cellular machinery. The first obstacle for the fungus to reach deep tissues is the epithelial barrier and this interaction is crucial for commensal growth, fungal pathogenicity and host defense. This study aimed to characterize in vitro epithelial HeLa cell invasion by four different isolates of C. albicans with distinct clinical backgrounds, including a C. albicans SC5314 reference strain. All isolates invaded HeLa cells, recruited actin and cortactin, and induced the phosphorylation of both Src-family kinases (SFK) and cortactin. Curiously, L3881 isolated from blood culture of a patient exhibited the highest resistance to oxidative stress, although this isolate showed reduced hyphal length and displayed the lowest cell damage and invasion rates. Collectively, these data suggest that the ability of C. albicans to invade HeLa cells, and to reach and adapt to the host's blood, including resistance to oxidative stress, may be independent of hyphal length.
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    Physical exercise alters the activation of downstream proteins related to BDNF-TrkB signaling in male Wistar rats with epilepsy
    (Wiley, 2018) Almeida, Alexandre Aparecido de [UNIFESP]; Silva, Sergio Gomes da; Lopim, Glauber Menezes [UNIFESP]; Campos, Diego Vannucci [UNIFESP]; Fernandes, Jansen [UNIFESP]; Cabral, Francisco Romero; Arida, Ricardo Mario [UNIFESP]
    There are a considerable number of studies concerning the behavioral effects of physical exercise on the epileptic brain
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    Specific structural features of syndecans and heparan sulfate chains are needed for cell signaling
    (Assoc Bras Divulg Cientifica, 2006-02-01) Lopes, Carla Cristina [UNIFESP]; Dietrich, Carl Peter [UNIFESP]; Nader, Helena Bonciani [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    The syndecans, heparan sulfate proteoglycans, are abundant molecules associated with the cell surface and extracellular matrix and consist of a protein core to which heparan sulfate chains are covalently attached. Each of the syndecan core proteins has a short cytoplasmic domain that binds cytosolic regulatory factors. the syndecans also contain highly conserved transmembrane domains and extracellular domains for which important activities are becoming known. These protein domains locate the syndecan on cell surface sites during development and tumor formation where they interact with other receptors to regulate signaling and cytoskeletal organization. the functions of cell surface heparan sulfate proteoglycan have been centered on the role of heparan sulfate chains, located on the outer side of the cell surface, in the binding of a wide array of ligands, including extracellular matrix proteins and soluble growth factors. More recently, the core proteins of the syndecan family transmembrane proteoglycans have also been shown to be involved in cell signaling through interaction with integrins and tyrosine kinase receptors.