Navegando por Palavras-chave "cardiovascular risk factors"

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    Breakfast frequency, adiposity, and cardiovascular risk factors as markers in adolescents
    (Cambridge Univ Press, 2016) Cayres, Suziane U.; Junior, Ismael F. F.; Barbosa, Mauricio F. [UNIFESP]; Christofaro, Diego G. D.; Fernandes, Romulo A.
    Objective To analyse the relationship between skipping breakfast and haemodynamic, metabolic, inflammatory, and cardiovascular risk factors in adolescents. Methods A cross-sectional study was carried out with information from an ongoing cohort study in Presidente Prudente, SAo Paulo, Brazil. The sample comprised of 120 adolescents (11.70.8 years old) who met the following inclusion criteria: age between 11 and 14 years; enrolled in the school unit of elementary education; absence of any known disease; and no drug consumption. The parents or legal guardians of the patients signed a formal informed consent. Skipping breakfast was self-reported through face-to-face interviews. Blood pressure, intima-media thickness, trunk fatness, total and fractional cholesterol levels - high-density lipoprotein cholesterol and low-density lipoprotein cholesterol - triacylglycerol levels, and high-sensitivity C-reactive protein levels were measured. Results In this study, 47.5% (95% CI: 38.5-56.4%) of the adolescents reported skipping breakfast at least 1 day/week. Adolescents who skipped breakfast had higher values of trunk fatness and systolic blood pressure. Breakfast frequency was negatively related to systolic blood pressure ( -1.99 [-3.67; -0.31]) and z score dyslipidaemia ( -0.46 [-0.90; -0.01]), but this relationship was mediated by trunk fatness. Conclusion Skipping breakfast is related to cardiovascular risk factors in adolescents, and this relationship was mainly mediated by trunk fatness.
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    Breakfast frequency, adiposity, and cardiovascular risk factors as markers in adolescents
    (Cambridge Univ Press, 2016) Cayres, Suziane U.; Junior, Ismael F. F.; Barbosa, Mauricio F. [UNIFESP]; Christofaro, Diego G. D.; Fernandes, Romulo A.
    Objective To analyse the relationship between skipping breakfast and haemodynamic, metabolic, inflammatory, and cardiovascular risk factors in adolescents. Methods A cross-sectional study was carried out with information from an ongoing cohort study in Presidente Prudente, SAo Paulo, Brazil. The sample comprised of 120 adolescents (11.70.8 years old) who met the following inclusion criteria: age between 11 and 14 years; enrolled in the school unit of elementary education; absence of any known disease; and no drug consumption. The parents or legal guardians of the patients signed a formal informed consent. Skipping breakfast was self-reported through face-to-face interviews. Blood pressure, intima-media thickness, trunk fatness, total and fractional cholesterol levels - high-density lipoprotein cholesterol and low-density lipoprotein cholesterol - triacylglycerol levels, and high-sensitivity C-reactive protein levels were measured. Results In this study, 47.5% (95% CI: 38.5-56.4%) of the adolescents reported skipping breakfast at least 1 day/week. Adolescents who skipped breakfast had higher values of trunk fatness and systolic blood pressure. Breakfast frequency was negatively related to systolic blood pressure ( -1.99 [-3.67; -0.31]) and z score dyslipidaemia ( -0.46 [-0.90; -0.01]), but this relationship was mediated by trunk fatness. Conclusion Skipping breakfast is related to cardiovascular risk factors in adolescents, and this relationship was mainly mediated by trunk fatness.
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    Macrovascular disease in a Japanese-Brazilian population of high prevalence of metabolic syndrome: Associations with classical and non-classical risk factors
    (Elsevier B.V., 2007-11-01) Siqueira, Antonela F. A.; Franco, Laercio J.; Gimeno, Suely G. A.; Matsumura, Luiza K.; Abdalla, Dulcineia S. P.; Barros, Newton de; Ferreira, Sandra R. G.; JBDSG; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
    Background: the Japanese-Brazilian Diabetes Study detected high prevalence of metabolic syndrome (MS) in a population of Japanese ancestry living in Brazil. We describe the prevalence of macrovascular disease (MVD) and its association with classical and non-classical cardiovascular risk factors in this population.Methods: An overall of 1163 individuals were studied; diagnosis of MVD was based on a score obtained from medical history, ankle-brachial pressure index and electrocardiogram, defining three groups: no MVD, possible MVD and definite MVD.Results: Prevalence of MVD was 14.3% (possible MVD: 11.2%; definite MVD: 3.1%). Individuals with MS had higher rates of MVD (16.9% versus 11.2%; p < 0.05). Comparing to no MVD, age, 2 It plasma glucose, anti-LDL(+) and anti-LDL(-) levels, and urinary albumin-to-creatinine ratio were higher in both categories with MVD; waist-to-hip ratio, fasting plasma glucose, HbAlc, total-to-HDL cholesterol ratio and triglycerides were higher in that with definite MVD; systolic blood pressure and homocysteine were higher in that with possible MVD. Using logistic regression, systolic blood pressure, smoking habit and anti-LDL(+) were independently associated with MVD.Conclusion: MVD is highly prevalent in Japanese-Brazilians and its association with MS was confirmed. A novel marker of lipoprotein modifications-anti-LDL(+) antibody-could be useful in identifying individuals at higher risk. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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    Metabolic profile and cardiovascular risk patterns of an Indian tribe living in the Amazon Region of Brazil
    (Wayne State Univ Press, 2003-02-01) Tavares, E. F.; Vieira, JPB; Andriolo, A.; Sanudo, A.; Gimeno, SGA; Franco, L. J.; Universidade Federal de São Paulo (UNIFESP)
    The Parkateje Indians, belonging to the Je group and inhabiting the Mae Maria Reservation in the southeast of the state of Para in the Amazon Region of Brazil, have suffered rapid and intensive cultural changes in recent years. This survey was designed to characterize the metabolic profile and the frequency of cardiovascular risk factors in this community. Ninety subjects (90.0% of the adult population without admixture) were investigated. Anthropometric measurements were performed and the following clinical characteristics measured: glycemia, serum insulin and proinsulin (fasting and 2-hr post 75 g of glucose load), beta-cell function (%B) and insulin sensitivity (%S) estimated by HOMA, HbA1c, GAD65 antibody, serum lipids, uric acid, creatinine, leptin, and blood pressure. Information about alcohol use, smoking, and medical history was obtained through individual interviews. the prevalences were: overweight, 67.8%; obesity, 14.4%; central obesity, 72.2%; hypertension, 4.4%; dyslipidemia, 44.4%; hyperuricemia, 5.6%; GAD65 antibody positivity, 4.4%; smoking, 25.6%; chronic alcohol use, 0.0%. One case of impaired glucose tolerance (1.1%) and one case of impaired fasting glycemia (1.1%) were diagnosed during this study and one case of diabetes (1.1%) was diagnosed previously. the diabetic woman was excluded from the analyses involving HbA1c, glycemia, insulin, proinsulin, %B, and %S. All creatinine values were normal. Blood pressure did not correlate with age, anthropometric measurements, insulin, proinsulin, and natural logarithm (In) transformed %S. After adjustment for age and sex, there were positive correlations between total cholesterol and body mass index (BMI; r = 0.24), triglycerides and BMI (r = 0.44), triglycerides and waist-to-hip ratio (WHR; r = 0.52), in leptin and BMI (r = 0.41), in leptin and WHR (r = 0.29), uric acid and systolic blood pressure (r = 0.34), uric acid and triglycerides (r = 0.22). Systolic (r = 0.04; r = 0.70) and diastolic (r = 0.14; p = 0.18) blood pressure did not correlate with BMI. Ln leptin had a weak positive correlation with 2-hr insulin (r = 0.14) adjusted for age, sex, and BMI. the multiple linear regression model containing the variables sex, BMI, and 2-hr insulin concentrations explained 77.2% of the variation of in leptin. in conclusion, the high rates of cardiovascular risk factors found among these Indians point to there being a high-risk group to develop diabetes and cardiovascular diseases. To reduce this risk they need to receive preventive interventions.
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    Serum total homocysteine levels and the prevalence of folic acid deficiency and C677T mutation at the MTHFR gene in an indigenous population of Amazonia: The relationship of homocysteine with other cardiovascular risk factors
    (Int Soc Hypertension Blacks-ishib, 2004-12-01) Tavares, Edelweiss Fonseca [UNIFESP]; Vieira Filho, João Paulo Botelho [UNIFESP]; Andriolo, Adagmar [UNIFESP]; Perez, Ana Beatriz Alvarez [UNIFESP]; Vergani, Naja [UNIFESP]; Sanudo, Adriana [UNIFESP]; Gimeno, Suely Godoy Agostinho [UNIFESP]; Franco, Laercio Joel [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Hyperhomocysteinemia is a risk factor for cardiovascular disease. C677T mutation at the MTHFR gene and deficiencies of folic acid and vitamin B-12 may account for elevation of total homocysteine (tHcy). Ninety Brazilian Parka-teje Indians (90.0% of the population without admixture, aged greater than or equal to20 years) were studied. Hyperhomocysteinemia was observed in 26.7% of the Indians. No case of vitamin B-12 deficiency was detected. Folic acid deficiency was found in 43.3% of the subjects. Rates of mutated allele 677T and TT genotype were 40.7% and 14.0%, respectively. Prevalence of hypertension, dyslipidemia, smoking, WHIR greater than or equal to0.9, BMI greater than or equal to25 kg/m(2) and chronic alcohol use were 4.4%, 44.4%, 25.6%, 72.2%, 67.8%, and 0.0%, respectively. All creatinine values were normal. Natural logarithmic (In) tHcy showed no correlation with age, but was positively correlated with systolic (r=0.22) and diastolic (r=0.21) blood pressure and triglycerides (r=0.39) and inversely correlated with folic acid (r= -0.40) adjusted for age and sex. Total homocysteine (tHcy) was higher among TT genotype (P<.001). The multiple linear regression model, containing variables for sex, folic acid, TT genotype, and triglycerides, explained 50.0% of the variation of the In tHcy. in summary, high rates of cardiovascular risk factors were discovered. C667T mutation and folic acid deficiency can explain, at least in part, the observed hyperhomocysteinemia.