Navegando por Palavras-chave "cardiac troponin"

Agora exibindo 1 - 2 de 2
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Cord blood cardiac troponin I, fetal Doppler velocimetry, and acid base status at birth
    (Elsevier B.V., 2008-02-01) Alexandre, Sandra Maria [UNIFESP]; D'Almeida, Vania [UNIFESP]; Guinsburg, Ruth [UNIFESP]; Nakamura, Mary U. [UNIFESP]; Tufik, Sergio [UNIFESP]; Moron, Antonio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Objective: To analyze the association between umbilical cord cardiac troponin I (cTnl), obstetric Doppler, and birth acidemia. Method: This prospective observational study was conducted on 58 singleton pregnancies at 3 Brazilian hospitals. Umbilical and middle cerebral artery Doppler velocimetry were performed 24 h prior to birth. At delivery, cord blood was collected for pH, blood gas analysis, and cTnl measurement. Results: Cardiac troponin I >= 0.20 ng/mL was detected in 5 neonates (8.6%). Centralization was recorded in 12 fetuses; 4 of these (33.3%) had detectable cTnl compared with 1/46 (2.2%) fetuses with normal Doppler (P=0.005). Acidemia was present in 60% of the neonates with detectable cTnl, compared with 15% of the neonates with undetectable cTnl (P=0.042). Conclusion: Centralization and birth acidemia are associated with detectable cTnl in cord blood supporting the possibility of myocardial ischemia in these fetuses. (c) 2007 Published by Elsevier Ireland Ltd. on behalf of International Federation of Gynecology and Obstetrics.
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    Remote ischemic preconditioning in myocardial protection in hemodialysis patients
    (Dove Medical Press Ltd, 2018) Bacci, Marcelo R.; Vasconcelos, Livia Y.; Murad, Neif; Chagas, Antonio Carlos P.; Capuano, Ana Carolina; Alves, Beatriz C. A.; Pereira, Edimar C. [UNIFESP]; Azzalis, Ligia A. [UNIFESP]; Junqueira, Virginia B. C. [UNIFESP]; Fonseca, Fernando L. A. [UNIFESP]
    Background: Remote ischemic preconditioning (RIPC) is a procedure that generates a brief period of ischemia followed by reperfusion. The role of RIPC in protecting myocardial ischemia during hemodialysis is not yet established. The aim of the study was to evaluate RIPC myocardial protection as evaluated by ultrasensitive I troponin in hemodialysis outpatients. Patients and methods: A double-blind randomized trial with two groups: intervention submitted to RIPC and control group without RIPC. Intervention group received RIPC in three consecutive hemodialysis sessions. Blood samples were taken before and after each session. Blood urea nitrogen for calculation of single-pool Kt/v and ultrasensitive I troponin were measured to evaluate dialysis adequacy and myocardial injury. Results: A total of 47 patients were randomized. About 60.8% were men and 54% were diabetic. The mean single-pool Kt/v was 1.51 in the intervention group and 1.49 in control. The ultrasensitive troponin I measured no significant change from the time of collection: before or after dialysis. Conclusion: The RIPC applied in three consecutive sessions did not demonstrate superiority to control, therefore another study tested RIPC in 12 consecutive sessions with a positive result in myocardial protection. In our study, more than half of the patients were diabetic. Diabetic patients have a trend to show a lower response to RIPC because of the greater presence of collateral coronary circulation. In summary, in this model there was no interference of RIPC in ultrasensitive troponin I values, but troponin had a high negative predictive value for myocardial infarction in all tested models.