Navegando por Palavras-chave "carbamazepine"

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    Carbamazepine damage to rat spermatogenesis in different sexual developmental phases
    (Wiley-Blackwell, 2009-10-01) Oliva, Samara Urban de [UNIFESP]; Miraglia, Sandra Maria [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    P>Carbamazepine (CBZ) is a first-line antiepileptic drug (AED), although it is also utilized for treatment of psychiatric disorders and neuropathic pain. the utilization of CBZ has been associated with damage to male reproduction including hormonal alterations, sexual dysfunction and reduction of sperm quality. Wide and long-term use of CBZ has been a common schedule for children and adolescents, despite the fact it alters the testosterone level in adult rats and humans. in addition, hypothalamic-pituitary-gonadal (HPG) axis during pre-puberty and puberty is more susceptible to toxic agents than in adult phase. the objective of this work was to evaluate the side effects of CBZ on the spermatogenic process of rats from pre-puberty to puberty and sexual maturation. Damage on the seminiferous epithelium, testicular interstitial oedema, reductions of testosterone levels and an increase in oestradiol levels were observed in rats, which were CBZ-treated since the weaning. the results suggest that CBZ, when administered from pre-puberty, provokes specific side effects on rat testes, resulting in more severe damage in the adult phase.
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    Carbamazepine does not alter the intrinsic cardiac function in rats with epilepsy
    (Academia Brasileira de Neurologia - ABNEURO, 2010-08-01) Colugnati, Diego Basile [UNIFESP]; Arida, Ricardo Mario [UNIFESP]; Cysneiros, Roberta Monterazzo [UNIFESP]; Terra, Vera Cristina; Sonoda, Eliza Yumi de Freitas [UNIFESP]; Pansani, Aline Priscila [UNIFESP]; Scorza, Carla Alessandra [UNIFESP]; Cavalheiro, Esper Abrão [UNIFESP]; Scorza, Fulvio Alexandre [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Presbiterian Mackenzie University Center of Biological Sciences and Health Program Graduate Development Disorders; University of São Paulo Ribeirão Preto Medicine School Department of Neurosciences and Behavior Sciences
    Among the causes for sudden unexpected death (SUDEP) in epilepsy, the effects of antiepileptic drugs on the heart have been poorly explored. Based on this, the aim of our study was to evaluate the heart rate (in vivo and isolated ex vivo) and ventricular pressure (isolated ex vivo) of rats with and without epilepsy treated with carbamazepine. Four groups of adult, male Wistar rats (200-250 g) were studied: [A] control rats (n=8), received neither pilocarpine nor carbamazepine [B] carbamazepine-treated rats (n=8), received a daily dose of 120 mg/Kg, i.p. of carbamazepine for two weeks; [C] rats with epilepsy that received just saline solution (n=8); [D] rats with epilepsy that received a daily dose of 120 mg/Kg, i.p. of carbamazepine for two weeks (n=8). Our results showed significant increase in heart rate in animals with epilepsy (with and without the use of carbamazepine) when compared to the control groups in vivo. In contrast, we did not find differences during isolated ex vivo experiments comparing animals with and without epilepsy and despite the use of carbamazepine. Our results suggest that, in isolation, carbamazepine may not be a potential risk factor for sudden unexpected death in epilepsy.
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    Primary melanoma of Meckel's cave: case report
    (Academia Brasileira de Neurologia - ABNEURO, 2004-06-01) Falavigna, Asdrubal; Borba, Luis A. B.; Ferraz, Fernando Antonio Patriani [UNIFESP]; Almeida, Giovana Camargo De; Krindges Júnior, José Valentim; Fundação Universidade de Caxias do Sul; Evangélica Medical School; Universidade Federal de São Paulo (UNIFESP); Universidade de Caxias do Sul Faculdade de Medicina
    We present a case of trigeminal neuralgia with cranial normal magnetic resonance image (MRI) and computed tomography. The pain was not relieved by carbamazepine and microvascular decompression surgery was done. After two months the pain was similar to the condition before surgery. At this time, MRI showed an expansive lesion in Meckel's cave that was treated with radical resection by extra-dural approach. The pathologic examination revealed a primary melanoma. The follow-up after six months did not show abnormalities.
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    Uso potencial dos anticonvulsivantes no tratamento ambulatorial da dependência de álcool
    (Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro, 2006-01-01) Castro, Luís André [UNIFESP]; Couzi, Carla [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Currently three medications (disulfiram, naltrexone and acamprosate) are approved by the FDA to treat alcohol dependence by the FDA. The classical anticonvulsive drugs are rarely employed as an alternative because of their side effects, but the latest generation of anticonvulsants could be useful. The anticonvulsants can be a alternative to BZD and other pharmacological treatments in the prevention of complications during the detoxification therapy, because of the absence of addictive properties and a better adverse effects profile than classical anticonvulsant drugs. Anticonvulsants such as carbamazepine, valproic acid, gabapentin and topiramate have shown to be excellent treatment for alcohol withdrawal and for the prevention of alcohol relapse. Although none of these agents have been approved by the FDA yet, there is growing evidence in the literature to support their use.