Navegando por Palavras-chave "brown adipose tissue"

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    Disruption of beta3 adrenergic receptor increases susceptibility to DIO in mouse
    (Bioscientifica Ltd, 2016) Preite, Nailliw Zanini [UNIFESP]; Nascimento, Bruna Pascarelli Pedrico do [UNIFESP]; Muller, Cynthia R.; Americo, Anna Laura V.; Higa, Talita S.; Evangelista, Fabiana S.; Lancellotti, Carmen L.; Henriques, Felipe dos Santos; Batista, Miguel Luiz, Jr.; Bianco, Antonio C.; Ribeiro, Miriam O.
    The brown adipose tissue (BAT) mediates adaptive changes in metabolic rate by responding to the sympathetic nervous system through beta-adrenergic receptors (AR). Here, we wished to define the role played by the AR beta(3) isoform in this process. This study focused on the AR beta(3) knockout mice (AR beta 3KO), including responsiveness to cold exposure, diet-induced obesity, intolerance to glucose, dyslipidaemia and lipolysis in white adipose tissue (WAT). AR beta 3KO mice defend core temperature during cold exposure (4 degrees C for 5h), with faster BAT thermal response to norepinephrine (NE) infusion when compared with wild-type (WT) mice. Despite normal BAT thermogenesis, AR beta 3KO mice kept on a high-fat diet (HFD
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    Increase in skeletal muscle protein content by the ß-2 selective adrenergic agonist clenbuterol exacerbates hypoalbuminemia in rats fed a low-protein diet
    (Associação Brasileira de Divulgação Científica, 1998-06-01) Sawaya, Ana Lydia [UNIFESP]; Lunn, P.g.; Universidade Federal de São Paulo (UNIFESP); Dunn Nutritional Laboratory
    This investigation examined how the nutritional status of rats fed a low-protein diet was affected when the animals were treated with the ß-2 selective agonist clenbuterol (CL). Males (4 weeks old) from an inbred, specific-pathogen-free strain of hooded rats maintained at the Dunn Nutritional Laboratory were used in the experiments (N = 6 rats per group). CL treatment (Ventipulmin, Boehringer-Ingelheim Ltd., 3.2 mg/kg diet for 2 weeks) caused an exacerbation of the symptoms associated with protein deficiency in rats. Plasma albumin concentrations, already low in rats fed a low-protein diet (group A), were further reduced in CL rats (A = 25.05 ± 0.31 vs CL = 23.64 ± 0.30 g/l, P<0.05). Total liver protein decreased below the level seen in either pair-fed animals (group P) or animals with free access to the low-protein diet (A = 736.56 ± 26 vs CL = 535.41 ± 54 mg, P<0.05), whereas gastrocnemius muscle protein was higher than the values normally described for control (C) animals (C = 210.88 ± 3.2 vs CL = 227.14 ± 1.7 mg/g, P<0.05). Clenbuterol-treated rats also showed a reduction in growth when compared to P rats (P = 3.2 ± 1.1 vs CL = -10.2 ± 1.9 g, P<0.05). This was associated with a marked decrease in fat stores (P = 5.35 ± 0.81 vs CL = 2.02 ± 0.16 g, P<0.05). Brown adipose tissue (BAT) cytochrome oxidase activity, although slightly lower than in P rats (P = 469.96 ± 16.20 vs CL = 414.48 ± 11.32 U/BAT x kg body weight, P<0.05), was still much higher than in control rats (C = 159.55 ± 11.54 vs CL = 414.48 ± 11.32 U/BAT x kg body weight, P<0.05). The present findings support the hypothesis that an increased muscle protein content due to clenbuterol stimulation worsened amino acid availability to the liver and further reduced albumin synthesis causing exacerbation of hypoalbuminemia in rats fed a low-protein diet.
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    Melatonin Absence Leads to Long-Term Leptin Resistance and Overweight in Rats
    (Frontiers Media Sa, 2018) Buonfiglio, Daniella; Parthimos, Rafaela; Dantas, Rosana; Silva, Raysa Cerqueira; Gomes, Guilherme; Andrade-Silva, Jessica; Ramos-Lobo, Angela; Amaral, Fernanda Gaspar [UNIFESP]; Matos, Raphael; Sinesio Jr., Jose; Motta-Teixeira, Livia Clemente; Donato Jr., Jose; Reiter, Russel J.; Cipolla-Neto, Jose
    Melatonin (Mel), a molecule that conveys photoperiodic information to the organisms, is also involved in the regulation of energy homeostasis. Mechanisms of action of Mel in the energy balance remain unclear