Navegando por Palavras-chave "bone remodeling"

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    Bone Deposition, Bone Resorption, and Osteosarcoma
    (Wiley-Blackwell, 2010-09-01) Toledo, Silvia Regina Caminada de [UNIFESP]; Oliveira, Indhira Dias [UNIFESP]; Okamoto, Oswaldo Keith [UNIFESP]; Zago, Marco Antonio; Alves, Maria Teresa de Seixas [UNIFESP]; Garcia Filho, Reynaldo Jesus [UNIFESP]; Macedo, Carla Renata Donato Pacheco [UNIFESP]; Petrilli, Antonio Sergio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
    Bone deposition and bone resorption are ongoing dynamic processes, constituting bone remodeling. Some bone tumors, such as osteosarcoma (OS), stimulate focal bone deposition. OS is the most common primary bone tumor in children and young adults. A complex network of genes regulates bone remodeling and alterations in its expression levels can influence the genesis and progression of bone diseases, including OS. We hypothesized that the expression profiles of bone remodeling regulator genes would be correlated with OS biology and clinical features. We used real-time PCR to evaluate the mRNA levels of the tartrate-resistant acid phosphatase (ACP5), colony stimulating factor-1 (CSF1R), bone morphogenetic protein 7 (BMP7), collagen, type XI, alpha 2 (COL11A2), and protein tyrosine phosphatases zeta 1 (PTPRZ1) genes, in 30 OS tumor samples and correlated with clinical and histological data. All genes analyzed, except CSF1R, were differentially expressed when compared with normal bone expression profiles. in our results, OS patients with high levels of COL11A2 mRNA showed worse overall (p = 0.041) and event free survival (p = 0.037). Also, a trend for better overall survival was observed in patients with samples showing higher expression of BMP7 (p =0.067). COL11A2 overexpression and BMP7 underexpression could collaborate to OS tumor growth, through its central role in bone remodeling process. (C) 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:1142-1148, 2010
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    Impacto do exercício físico nos marcadores bioquímicos de remodelação óssea e homeostase mineral em crianças e adolescentes com doença celíaca obedientes à dieta sem glúten
    (Universidade Federal de São Paulo (UNIFESP), 2014-05-30) Damiati, Rosa Amelia [UNIFESP]; Sdepanian, Vera Lucia Sdepanian [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Objective: Assess the effects of physical exercise on biochemical markers of bone remodeling and mineral homeostasis in children and adolescents with celiac disease who compliance with gluten-free diet. Methods: We evaluated 24 patients with a mean age of 10.4 (2.6) years, 11 male, with celiac disease in obedience to the gluten free diet for over a year. All patients received supplemental calcium and vitamin D, aiming at achieving the recommendations of the RDA for age. The patients were divided into two groups: one group (n = 9) performed exercise of moderate impact four times a week for three months; another group did not perform physical exercise. Serum measurements were performed at baseline and after three months of bone formation markers P1nP and CTx bone resorption, 25OHD, intact parathyroid hormone, ionized calcium, phosphorus, magnesium, alkaline phosphatase, creatinine, albumin and urinary calcium. Results: After 3 months of exercise, the children had a mean concentration of the bone formation marker P1nP greater (p = 0,004) and higher 25OHD (p = 0,004) than those who did not engage in physical exercise, whereas adolescents did not show these differences . As for CTx and other biochemical markers of bone metabolism, there was no difference after 3 months of exercise in children and adolescents. In the group that did exercise, there was a correlation between P1nP before and after exercise (r = 0752, p = 0.020). Conclusions: The concentrations of the bone formation marker P1nP and 25OHD were higher after completion of exercise in children.