Navegando por Palavras-chave "beta-carotene"

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    beta-Carotene-loaded nanostructured lipid carriers produced by solvent displacement method
    (Elsevier Science Bv, 2016) Bernardes Oliveira, Davi Rocha; Michelon, Mariano; Furtado, Guilherme de Figueiredo; Sinigaglia-Coimbra, Rita [UNIFESP]; Cunha, Rosiane Lopes
    Tristearin solid lipid nanoparticles and tristearin/high oleic sunflower oil nanostructured lipid carriers were produced by solvent displacement method. All conditions allowed forming polydisperse particles within nanometric range and the presence of high oleic sunflower oil did not affect the particles mean size. Nevertheless, incorporation of beta-carotene reduced the particles polydispersity. Thermograms of solid lipid nanoparticles and nano structured lipid carriers showed that sunflower oil generated a crystal order disturbance, since nanoparticles with less-organized lipid matrix were produced. Nanostructured lipid carriers exhibited an improvement of beta-carotene loading capacity when compared with solid lipid nanoparticles, which enhanced with the increasing of high oleic sunflower oil content. Although total beta-carotene degradation was similar for all systems, color analysis showed that the degradation of encapsulated beta-carotene was lower for high sunflower oil content. Nano structured lipid carriers exhibited advantages over the solid lipid nanoparticles, such as enhanced drug loading capacity and prevention of drug expulsion, which makes this a versatile delivery system for food applications. (C) 2016 Elsevier Ltd. All rights reserved.
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    Both human immunodeficiency virus-infected and human immunodeficiency virus-exposed, uninfected children living in Brazil, Argentina, and Mexico have similar rates of low concentrations of retinol, beta-carotene, and vitamin E
    (Elsevier B.V., 2009-10-01) Monteiro, Jacqueline P.; Freimanis-Hance, Laura; Faria, Lidiane B.; Mussi-Pinhata, Marisa M.; Korelitz, James; Vannucchi, Helio; Queiroz, Wladimir; Succi, Regina C. M. [UNIFESP]; Hazra, Rohan; Eunice Kennedy Shriver Natl Inst Child Hlth & Hum; Universidade de São Paulo (USP); WESTAT Corp; Inst Infectol Emilio Ribas; Universidade Federal de São Paulo (UNIFESP)
    Our objective was to describe the prevalence of low concentrations of retinol, beta-carotene, and vitamin E in a group of human immunodeficiency virus (HIV)-infected Latin American children and a comparison group of HIV-exposed, uninfected children. Our hypothesis was that the rates of low concentrations of these micronutrients would be higher in the HIV-infected group than those in the HIV-exposed, uninfected group. This was a cross-sectional substudy of a larger cohort study at clinical pediatric HIV centers in Latin America. Serum levels of micronutrients were measured in the first stored sample obtained after each child's first birthday by high-performance liquid chromatography. Low concentrations of retinol, beta-carotene, and vitamin E were defined as serum levels below 0.70, 0.35, and 18.0 mu mol/L, respectively. the Population for this analysis was 336 children (124 HIV-infected, 212 HIV-exposed, uninfected) aged I year or older to younger than 4 years. Rates of low concentrations were 74% for retinol, 27% for beta-carotene, and 89% for vitamin E. These rates were not affected by HIV status. Among the HIV-infected children, those treated with anti retrovirals were less likely to have retinol deficiency, but no other HIV-related factors correlated with micronutrient low serum levels. Low concentrations of retinol, beta-carotene, and vitamin E are very common in children exposed to HIV living in Brazil, Argentina, and Mexico, regardless of HIV-infection status. Published by Elsevier Inc.