Navegando por Palavras-chave "anosmia"

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    Topical Dexamethasone Administration Impairs Protein Synthesis and Neuronal Regeneration in the Olfactory Epithelium
    (Frontiers Media Sa, 2018) Crisafulli, Umberto [UNIFESP]; Xavier, Andre Machado [UNIFESP]; Santos, Fabiana B. dos [UNIFESP]; Cambiaghi, Tavane David [UNIFESP]; Chang, Seo Y. [UNIFESP]; Porcionatto, Marimélia Aparecida [UNIFESP]; Castilho, Beatriz Amaral de [UNIFESP]; Malnic, Bettina; Glezer, Isaias [UNIFESP]
    Chronic inflammatory process in the nasal mucosa is correlated with poor smell perception. Over-activation of immune cells in the olfactory epithelium (OE) is generally associated with loss of olfactory function, and topical steroidal anti-inflammatory drugs have been largely used for treating such condition. Whether this therapeutic strategy could directly affect the regenerative process in the OE remains unclear. In this study, we show that nasal topical application of dexamethasone (DEX