Navegando por Palavras-chave "ankle-brachial index"

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    Asymptomatic Atherosclerosis in Primary Sjogren Syndrome: Correlation Between Low Ankle Brachial Index and Autoantibodies Positivity
    (Lippincott Williams & Wilkins, 2016) Andreo Garcia, Ana Beatriz [UNIFESP]; Dardin, Luciana Paula [UNIFESP]; Minali, Paulo Alexandre [UNIFESP]; Czapkowsky, Adriano [UNIFESP]; Ajzen, Sergio Aron [UNIFESP]; Moca Trevisani, Virginia Fernandes [UNIFESP]
    Background Primary Sjogren syndrome is a chronic inflammatory autoimmune disease. The delay in diagnosis allows the establishment of a chronic inflammatory state, which makes primary Sjogren syndrome an interesting model for the study of atherosclerosis. Objectives The aim of this study was to evaluate subclinical atherosclerosis in 49 patients with Sjogren syndrome using noninvasive methods. Methods We assessed traditional risk factors such as hypertension, diabetes, dyslipidemia, smoking, and family history of atherosclerosis. Patients with prior cardiovascular events and a history of atherosclerosis were excluded. Clinical and laboratory features were recorded, as well as the European League Against Rheumatism Sjogren's Syndrome Activity Index calculation. The atherosclerosis evaluation was done by carotid intima-media thickness, measured by ultrasonography, and ankle-brachial index (ABI). Results Fifteen patients (31%) had at least 1 traditional risk factor, and 65.3% had a European League Against Rheumatism Sjogren's Syndrome Activity Index score from mild to moderate. Only 2 patients had increased carotid intima-media thickness. However, 59% presented ABI alterations. Multiple correspondence analysis showed a clear correlation between low ABI and the positivity of autoantibodies (antinuclear antibodies, anti-SSA, rheumatoid factor). Conclusions The subgroup of patients with positive autoantibodies showed low ABI, which may represent a higher risk of early atherosclerosis and indicate the need for more careful monitoring in this group.
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    Relation between the ankle-brachial index and the complexity of coronary artery disease in older patients
    (Dove Medical Press Ltd, 2013-01-01) Falcão, Felipe José de Andrade [UNIFESP]; Alves, Claudia Maria Rodrigues [UNIFESP]; Caixeta, Adriano [UNIFESP]; Guimaraes, Leonardo de Freitas [UNIFESP]; Sousa Filho, Juscelio Trajano de [UNIFESP]; Soares, Juliana A. [UNIFESP]; Helber, Izo [UNIFESP]; Carvalho, Antonio C. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Background: in the elderly, the ankle-brachial index (ABI) has greater than 90% sensitivity and specificity for peripheral artery disease identification. A well-known relation exists between peripheral artery disease and the number of diseased coronary vessels. Yet, other anatomical characteristics have important impacts on the type of treatment and prognosis.Purpose: To determine the relation between ABI and the complexity of coronary artery disease, by different anatomical classifications.Methods: This study was a prospective analysis of patients >= 65 years old who were undergoing elective coronary angiography for ischemic coronary disease. the ABI was calculated for each leg, as the ratio between the lowest ankle pressure and the highest brachial pressure. the analysis of coronary anatomy was performed by three interventional cardiologists; it included classification of each lesion with >50% diameter stenosis, according to the American Heart Association criteria, and calculation of the SYNTAX score.Results: the study recruited 204 consecutive patients (median age: 72.5 years). Stable angina was present in 51% of patients. Although only 1% of patients reported peripheral artery disease, 45% exhibited an abnormal ABI. the number of lesions per patient, the number of patients with complex lesions, and the median SYNTAX scores were greater in the group with abnormal ABI. However, among 144 patients with obstructive coronary artery disease, despite abnormal ABI being able to identify a higher rate of patients with B2 or C type lesions (70.9% versus 53.8%; P=0.039), the mean SYNTAX scores (13 versus 9; P=0.14), and the proportion of patients with SYNTAX score >16 (34.2% versus 27.7%; P=0.47), were similar, irrespective of ABI.Conclusion: in patients >65 years old the presence of peripheral artery disease could discriminate a group of patients with greater occurrence of B2 and C type lesions, but similar median SYNTAX score.