Navegando por Palavras-chave "amidinopyrazole"

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    Ultrasound-Promoted Synthesis of 3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1carboximidamides and Anticancer Activity Evaluation in Leukemia Cell Lines
    (Soc Brasileira Quimica, 2017) dos Santos, Eric F. S.; Cury, Nathalia M.; do Nascimento, Tainara A.; Raminelli, Cristiano [UNIFESP]; Casagrande, Gleison A.; Pereira, Claudio M. P.; Simionatto, Euclesio; Yunes, Jose A.; Pizzuti, Lucas
    3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboximidamides were efficiently prepared through a cyclocondensation of thiophenylchalcones with aminoguanidine hydrochloride under ultrasonic conditions in the presence of KOH and ethanol as a green solvent in short reaction times (15-35 min) and good yields (62-95%). All compounds produced were evaluated against the human Jurkat and RS4