Navegando por Palavras-chave "adaptive thermogenesis"

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    Disruption of beta3 adrenergic receptor increases susceptibility to DIO in mouse
    (Bioscientifica Ltd, 2016) Preite, Nailliw Zanini [UNIFESP]; Nascimento, Bruna Pascarelli Pedrico do [UNIFESP]; Muller, Cynthia R.; Americo, Anna Laura V.; Higa, Talita S.; Evangelista, Fabiana S.; Lancellotti, Carmen L.; Henriques, Felipe dos Santos; Batista, Miguel Luiz, Jr.; Bianco, Antonio C.; Ribeiro, Miriam O.
    The brown adipose tissue (BAT) mediates adaptive changes in metabolic rate by responding to the sympathetic nervous system through beta-adrenergic receptors (AR). Here, we wished to define the role played by the AR beta(3) isoform in this process. This study focused on the AR beta(3) knockout mice (AR beta 3KO), including responsiveness to cold exposure, diet-induced obesity, intolerance to glucose, dyslipidaemia and lipolysis in white adipose tissue (WAT). AR beta 3KO mice defend core temperature during cold exposure (4 degrees C for 5h), with faster BAT thermal response to norepinephrine (NE) infusion when compared with wild-type (WT) mice. Despite normal BAT thermogenesis, AR beta 3KO mice kept on a high-fat diet (HFD