Navegando por Palavras-chave "abdominal surgery"

Agora exibindo 1 - 2 de 2
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Generic Versus Branded Enoxaparin in the Prevention of Venous Thromboembolism Following Major Abdominal Surgery: Report of an Exploratory Clinical Trial
    (Sage Publications Inc, 2011-11-01) Gomes, Marise; Ramacciotti, Eduardo; Henriques, Alexandre Cruz; Araujo, Gilson Roberto; Szultan, Luiz Arnaldo; Miranda, Fausto [UNIFESP]; Thethi, Indermohan; Loyola Univ; Hosp Base Brasilia; Irmandade Santa Casa Misericordia São Paulo; Universidade Federal de São Paulo (UNIFESP); Aurora Mem Hosp
    Introduction: Several generic low-molecular-weight heparins (LMWHs) have recently become available worldwide, including the United States. Companies have filed for regulatory approval of generic versions in many countries, based only on compound biochemical characteristics or its immunogenicity. Methods: Prospective study to evaluate the comparative effect of 2 enoxaparins (Sanofi-Aventis branded enoxaparin [SAe] vs eurofarma-enoxaparin [Ee], a generic version) as prophylaxis for venous thromboembolism (VTE) following major abdominal surgery. A total of 200 patients were randomized in a 1:1 ratio either to receive 40 mg of SAe or Ee subcutaneously (sc) once daily (od) postoperatively for 7 to 10 days. Compressive ultrasound was performed on day 10 + 4. Results: No statistically significant differences between the 2 groups were detected. in all, 2 SAe patients presented deep vein thrombosis ([DVT] 2.1%), none of the Ee group. No major bleeding events occurred. Conclusions: This exploratory trial suggests that the generic LMWH is probably as safe and as effective as the branded enoxaparin (Lovenox, Brazil) in the prophylaxis of VTE in this population.
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    Prospective assessment of the risk of postoperative pulmonary complications in patients submitted to upper abdominal surgery
    (Associação Paulista de Medicina - APM, 1999-07-01) Pereira, Eanes Delgado Barros; Fernandes, Ana Luisa Godoy [UNIFESP]; Anção, Meide Silva [UNIFESP]; Peres, Clovis de Araujo [UNIFESP]; Atallah, Álvaro Nagib [UNIFESP]; Faresin, Sonia Maria [UNIFESP]; Federal University of Ceará; Universidade Federal de São Paulo (UNIFESP); University of São Paulo; São Paulo Hospital
    OBJECTIVE: To investigate associations between preoperative variables and postoperative pulmonary complications (PPC) in elective upper abdominal surgery. DESIGN: Prospective clinical trial. SETTING: A tertiary university hospital. PATIENTS: 408 patients were prospectively analyzed during the preoperative period and followed up postoperatively for pulmonary complications. MEASUREMENTS: Patient characteristics, with clinical and physical evaluation, related diseases, smoking habits, and duration of surgery. Preoperative pulmonary function tests (PFT) were performed on 247 patients. RESULTS: The postoperative pulmonary complication rate was 14 percent. The significant predictors in univariate analyses of postoperative pulmonary complications were: age >50, smoking habits, presence of chronic pulmonary disease or respiratory symptoms at the time of evaluation, duration of surgery >210 minutes and comorbidity (p <0.04). In a logistic regression analysis, the statistically significant predictors were: presence of chronic pulmonary disease, surgery lasting >210 and comorbidity (p <0.009).CONCLUSIONS: There were three major clinical risk factors for pulmonary complications following upper abdominal surgery: chronic pulmonary disease, comorbidity, and surgery lasting more than 210 minutes. Those patients with three risk factors were three times more likely to develop a PPC compared to patients without any of these risk factors (p <0.001). PFT is indicated when there are uncertainties regarding the patient s pulmonary status.