Navegando por Palavras-chave "Vitamin D deficiency"
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- ItemAcesso aberto (Open Access)Estudo de associação entre concentração sérica de vitamina D e características sociodemográficas, antropométricas e bioquímicas em crianças e adolescentes com excesso de peso de comunidades de baixa renda no Sudeste do Brasil(Universidade Federal de São Paulo (UNIFESP), 2019-01-31) Patriota, Pollyanna Fernandes [UNIFESP]; Sawaya, Ana Lydia [UNIFESP]; Ribeiro, Eliane Beraldi [UNIFESP]; http://lattes.cnpq.br/6518739448365292; http://lattes.cnpq.br/6388185949585379; http://lattes.cnpq.br/5770838139941225; Universidade Federal de São Paulo (UNIFESP)Objectives: systematization and publication of a research protocol for the analysis of a multicomponent and environmental intervention focused on recovering the nutritional status of overweight children and adolescents living in low-income communities in the city of São Paulo, Southeast Brazil, as well as investigating the association between serum concentration of 25(OH)D and sociodemographic, anthropometric and biochemical characteristics in Brazilian children and adolescents (8 to 12 years old) in this same population. Methods: The sample was composed of 196 participants of both genders (BMI for age >1 z score) ages 8 to 12, of two public schools of southeast Brazil. The multivariate linear regression analysis included biochemical and sociodemographic parameters with adjustments for age, gender, and pubertal stage. Results: Serum levels of vitamin D were insufficient/deficient in 84.2% (n=165/196) of the participants. In multivariate analysis, serum 25(OH)D concentration showed a negative association with having access at home internet (β= -2.71; p =0.01), total serum cholesterol (β= -0.05; p = 0.03), phosphorus (β = -2.54; p = 0.03) and PTH (β= -4.57; p=0.06). Conclusions: There was a high prevalence of 25(OH)D deficiency in overweight children and adolescents of low income; 25(OH)D levels were inversely associated with biochemical parameters(PTH, total cholesterol and phoshorus) and acess to home internet.
- ItemSomente MetadadadosThe Role of Vitamin D in Pathophysiology and Treatment of Fibromyalgia(Springer, 2013-08-01) Jesus, Carlos A. S. [UNIFESP]; Feder, David; Peres, Mario F. P. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); ABCRecent studies showed that most cells have receptors and enzymes responsible for metabolism of vitamin D. Several diseases have been linked to vitamin D deficiency, such as hypertension, diabetes, depression, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and chronic pain syndromes such as fibromyalgia. the association between fibromyalgia and vitamin D deficiency is very controversial in the literature with conflicting studies and methodological problems, which leads to more questions than answers. the purpose of this article is to raise questions about the association of hypovitaminosis D with fibromyalgia considering causal relationships, treatment, and pathophysiological explanations.
- ItemSomente MetadadadosSecondary hyperparathyroidism and its relationship with sarcopenia in elderly women(Elsevier B.V., 2015-03-01) Genaro, Patricia de Souza; Pinheiro, Marcelo de Medeiros [UNIFESP]; Szejnfeld, Vera Lucia [UNIFESP]; Martini, Ligia Araujo; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)Low dietary intake of calcium and poor vitamin D status during aging can result in mild secondary hyperparathyroidism, which may be associated with low muscle mass and reduced strength in the elderly. the aim of this study was to investigate whether low vitamin D, high parathormone (PTH), or both, are associated with sarcopenia. A total of 105 women, 35 with sarcopenia and 70 without sarcopenia, were enrolled in the present study. Body composition measurements were performed by DXA and sarcopenia was defined as skeletal muscle mass index < 5.45 kg/m(2) and grip strength lower than 20 kg. Three-day dietary records were taken and adjustments for energy intake made. the estimated average requirement (EAR) method was adopted as a cut-off point for estimating the prevalence of inadequate intake. Serum total calcium, phosphorus, creatinine, intact PTH, and 25(OH) D were measured. Only 1% of the patients met the daily adequate intake for vitamin D and 11% met the daily adequate intake for calcium. Notably, the prevalence of sarcopenia was higher in hyperparathyroidism (25(OH)D < 20 ng/mL and PTH > 65 pg/dL) than in the absence of hyperparathyroidism (41.2 vs 16.2%, respectively; p = 0.046). the odds ratio for sarcopenia in hyperparathyroidism cases was 6.81 (95% CI 1.29-35.9) compared with participants who had low PTH and a high 25(OH) D concentration. the present study showed that vitamin D insufficiency associated with secondary hyperparathyroidism increased the risk of sarcopenia, suggesting that the suppression of hyperparathyroidism by ensuring adequate calcium and vitamin D intake should be considered in interventional studies to confirm potential benefits. (C) 2015 Elsevier Ireland Ltd. All rights reserved.